2010
Bahrami, J., Longuet, C., Baggio, L.L., Li, K., and Drucker, D. J. The glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse Gastroenterology 2010 in press
Drucker, D. J., Dritselis, A., Fitzpatrick, P. Liraglutide Nature Reviews Drug Discovery 2010 9:267-268
Bahrami, J., Yusta, B., and Drucker, D. J. ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel Gastroenterology 2010 in press
Buse, J. B., Drucker, D. J., Taylor, K. L., Kim, T., Walsh, B., Hu, H., Wilhelm, K., Trautmann, M., Shen, L. Z., Porter, L. E., and the DURATION 1 Study Group DURATION-1: Exenatide Once Weekly Produces Sustained Glycemic Control and Weight Loss Over 52 Weeks Diabetes Care published ahead of print March 9, 2010, doi:10.2337/dc09-1914
Knudsen, L. B., Madsen, L.W., Andersen, S., Almholt, K., de Boer, A. S., Drucker, D. J., Gotfredsen, C., Egerod, F. L., Hegelund, A. C., Jacobsen, H., Jacobsen, S. D., Moses, A. C., Molck, A. M., Nielsen, H. S., Nowak, J., Solberg, H., Thi, T. D. L., Zdravkovic, M. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation Endocrinology 2010 151: 1473-1486
Ban, K., Kim, K.-H., Cho, C.-K., Sauvé, S., Diamandis, E. P., Backx, P. H., Drucker, D. J., and Husain, M. GLP-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor Endocrinology 2010 151: 1520-1531
Drucker, D. J., Sherman, S. I., Gorelick, F. S., Bergenstal, R. M., Sherwin, R. S., and Buse, J. B. Incretin-based therapies for the treatment of type 2 diabetes; evaluation of the risks and benefits Diabetes Care 2010 33:428-433
Sauve, M., Ban, K., Momen, M. A., Zhou, Y-Q., Henkelman, R. M., Husain, M., and Drucker, D. J. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes following myocardial infarction in mice Diabetes 2010 Apr;59(4):1063-73
Hadjiyanni, I., Siminovitch, K. A., Danska, J. S., Drucker D. J. Glucagon-like peptide-1 receptor (GLP-1R) signaling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T-cells Diabetologia 2010 Apr;53(4):730-40
Hsieh, J., Longuet, C., Baker, C. L., Qin, B., Federico, L. M., Drucker, D. J., Adeli, K. The glucagon-like peptide-1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice Diabetologia 2010 Mar;53(3):552-61.
2009
Barrera, J. G., D'Alessio, D. A., Drucker, D. J., Woods, S. C., and Seeley, R. J. Differences in the central anorectic effects of GLP-1 and exendin-4 in rats Diabetes 2009 Dec;58(12):2820-7
Maida, A., Hansotia, T., Longuet, C., Seino, Y., Drucker, D. J. Differential importance of GIP vs. GLP-1 receptor signaling for beta cell survival in mice Gastroenterology 2009 137 (6), December 2009, 2146-2157
Belsham, D. D., Fick, L. J., Dalvia, P. S., Centeno, M.-L., Chalmers, J. A., Lee, P. K. P., Yang, Y., Drucker, D. J., and Koletar, M. M. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis allowing immortalization of adult murine hypothalamic neurons FASEB J. 2009 Dec; 23 (12):4256-65
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, Z., Mastronardi, F., Maezawa, Y., Drucker, D. J., Engleman, E., Winer, D., and Dosch, H.-M. Normalization of obesity-associated insulin-resistance through immunotherapy Nature Medicine 2009 (15) 921-929
Day, J., Ottaway, N., Patterson, J., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D.J., Chaudhary, N., Holland, J., Hembree, J., Abplanalp, W., Grant, E., Ruehl, J., Wilson, H., Kirchner, H., Lockie, S., Hofmann, S., Woods, S., Nogueiras, R., Pfluger, P., Perez-Tilve, D., DiMarchi, R., and Tschop, M. A novel glucagon/GLP-1 co-agonist eliminates obesity in rodents Nature Chemical Biology 2009 Oct;5(10):749-57
Yusta, B., Holland, D., Koehler, J.A., Maziarz, M., Estall, J. L., Higgins, R., Drucker, D. J. ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut Gastroenterology
Sep;137(3):986-96.
Koehler, J. K., Baggio, L. L., Lamont, B. J., Ali, S., and Drucker D. J. GLP-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice Diabetes 2009 58:2148-2161
Ban, K., Hui, S., Drucker, D. J., and Husain, M. Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin-based therapies 2009 Journal of the American Society of Hypertension DOI: 10.1016/ July 2009 Vol. 3 (4) 245-259
Hsieh J, Longuet C, Maida A, Bahrami J, Xu E, Baker CL, Brubaker PL, Drucker DJ, Adeli K. Glucagon-like Peptide-2 Increases Intestinal Lipid Absorption and Chylomicron Production via CD36 Gastroenterology. 2009 Sep;137(3):997-1005
Lovshin, J. A. and Drucker D. J. Incretin-based therapies for type 2 diabetes mellitus Nature Reviews Endocrinology 2009 5(5) 262-269
Noyan-Ashraf M. H., Momen M. A., Ban K., Sadi A. M., Zhou Y. Q., Riazi, A. M., Baggio L. L., Henkelman R.M., Husain M., Drucker D. J. The GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes following experimental myocardial infarction in mice. Diabetes 2009 Apr;58(4):975-83.
Ali, S., and Drucker D. J. Am J Physiol Endo Metab Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes Am J Physiol Endocrinol Metab Mar 2009; 296:E415-E421
Ayala, J., Bracy, D. P., James, F. D., Julien, B. M., Wasserman, D. H., and Drucker, D. J. The Glucagon-like Peptide-1 Receptor Regulates Endogenous Glucose Production and Muscle Glucose Uptake Independent of its Incretin Action Endocrinology 2009 Mar;150(3):1155-64
Hadjiyanni, I, Li, K., and Drucker D. J. Glucagon like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the non obese diabetic mouse Endocrinology 2009 Feb;150(2):592-9
Martin, B., Dotson, C. D., Shin, Y. K., Ji, S., Drucker, D. J., Maudsley, S., and Munger, S. D. Modulation of taste sensitivity by GLP-1 signaling in taste buds Annals of the New York Academy of Sciences 2009 1170:98-101
Duez, H., Smith, A.C., Xiao, C., Giacca, A., Szeto, L., Drucker, D.J., and Lewis, G. F. Acute DPP-4 Inhibition rapidly Enhances Insulin-mediated Suppression of Endogenous Glucose Production in Mice Endocrinology 2009 Jan;150(1):56-62
2008
Longuet, C., Sinclair, E.M., Maida, A., Baggio, L.L., Maziarz, M., Charron, M.J., and Drucker, D.J. Glucagon is essential for control of hepatic lipid metabolism and the adaptive metabolic response to fasting Cell Metabolism 2008:8; 359-371
Koehler, J. A., Harper, W., Barnard, M., Yusta, B., and Drucker D. J. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells Can Res 2008 68:7897-7904
Drucker, D. J., Buse, J.B., Taylor, K., Kendall, D., Trautmann, M., Zhuang, D., Porter, L. 2008 Exenatide Once Weekly versus Twice Daily for the Treatment of Type 2 Diabetes Lancet 2008 372:1240-50
Patel, S., Doble, B. W., MacAulay, K., Sinclair, E. M. Drucker, D. J. and. Woodgett, J. R. Tissue-specific role of glycogen synthase kinase-3 in glucose homeostasis and insulin action Mol. Cell. Biol. 2008:28;6314-6328
Sinclair, E.M., Yusta, B., Streutker, C., Baggio, L.L., Koehler, J., Charron, M.J., and Drucker D. J. Glucagon receptor signaling is essential for control of murine hepatocyte survival Gastroenterology 2008 Dec;135(6):2096-106
Maida, A., Lovshin, J. L., Baggio, L.L. and Drucker D. J. The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice Endocrinology 2008 149;5670-5678
Cabou, C., Campistron, Marsollier, G. N., Corinne Leloup, C., Cruciani-Guglielmacci, C., Pénicaud, L., Drucker, D. J., Magnan, C., and Burcelin, R. Brain GLP-1 regulates arterial blood flow, heart rate and insulin sensitivity Diabetes Oct;57(10):2577-87.
Knauf, C., Cani, P. D., Kim, D.-H., Iglesias, M. A., Chabo, C., Waget, A., Colom, A., Rastrelli, S., Delzenne, N.M., Drucker, D. J., Seeley, R. J., and Burcelin, R. The role of CNS GLP-1 receptors in enteric glucose sensing Diabetes 2008 57:2603-2612
Retnakaran, R., and Drucker, D.J. Intensive insulin therapy in newly diagnosed type 2 diabetes Lancet 2008 371:1725-1726
Picha, K. M., Cunningham, M. R., Drucker, D. J., Mathur, A., Ort, T., Scully, M., Soderman, A., Spinka-Doms, T., Stojanovic-susulic, V., Thomas, B. A., and O’Neil, T. Protein engineering strategies for sustained GLP-1R-dependent control of glucose homeostasis Diabetes 2008 Jul;106(1):455-63
Ban, K., Noyan-Ashraf, M. H., Hoefer, J., Bolz, S.-S., Drucker, D. J., and Husain, M. Cardioprotective and vasodilatory actions of GLP-1 are mediated through both GLP-1 receptor-dependent and independent pathways Circulation 2008 May 6;117(18):2340-50.
Shin, Y. K., Martin, B., Golden, E., Dostson, C. D., Maudsely, S., Kim, W., Jang, H. J., Mattson, M. P., Drucker, D. J., Egan, J. M., and Munger, S. D. Modulation of taste sensitivity by GLP-1 signaling J. Neurochem 2008 Jul;106(1):455-63
Ayala, J. E., Bracy, D. P., Hansotia, T., Flock, G., Seino, Y., Wasserman, D. H., and Drucker, D. J. Insulin action in the double incretin receptor knockout mouse Diabetes 2008 57: 288 -297
Hadjiyanni, I., Baggio, L. L., Poussier, P., and Drucker, D.J. Endocrinology 2008 Mar;149(3):1338-49
Kumar, K. G., Byerley, L., Volaufova, J., Drucker, D. J., Churchill, G. A., Li, R., York, B., Zuberi, A., Smith Richards, B. K. Genetic variation in Glp1r expression influences the rate of gastric emptying in mice. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R362-71
Yamada, C., Yamada, Y., Tsukiyama, K., Yamada, K., Udagawa, N., Takahashi, N., Tanaka, K., Drucker, D. J., Seino, Y., and Inagaki, N. The murine Glp1r is essential for control of bone resorption Endocrinology 2008 149: 574-579
Goldberg, R. B., Holman, R., and Drucker D. J. Management of type 2 diabetes New Eng J Med 2008 358:293-297
Baggio, L. L., Cao, X., Huang, Q., and Drucker, D. J.. An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis Gastroenterology 2008, Apr; 134(4): 1137-47
Lamont, B., and Drucker, D. J. Differential anti-diabetic efficacy of incretin agonists vs. DPP-4 inhibition in high fat fed mice Diabetes 2008 57: 190 -198
2007
Hadjiyanni, I., and Drucker, D. J. Glucagon-Like Peptide 1 and Type 1 Diabetes: NOD Ready for Prime Time? Endocrinology. 2007 Nov;148(11):5133-5
Wideman, R. D., Covey, S. D., Webb, G. C., Drucker, D. J., Kieffer, T. A Switch from PC2 to PC1/3 Expression in Transplanted {alpha}-cells is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice. Diabetes. 2007 56:2744-2752, 2007
Macaulay, K., Doble, B. W., Patel, S., Hansotia, T., Sinclair, E. M., Drucker, D. J., Nagy, A., and Woodgett, J. R. Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism Cell Metab 2007 (6) 329-337
Flock, G., Baggio, L. L., Longuet, C., and Drucker, D. J. The incretin receptors for GLP-1 and GIP are essential for the sustained metabolic actions of vildagliptin in mice Diabetes 2007 :56:3006-3013
Cani, P. D., Holst, J.J., Drucker, D. J., Delzenne, N. M., Thorens, B., Burcelin, R., and Knauf, C. GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol. 2007 Sep 30;276(1-2):18-23
Baggio, L. L. and Drucker, D. J. Biology of Incretins: GLP-1 and GIP Gastroenterology, Volume 132, Issue 6, May 2007, Pages 2131-2157
Drucker, D. J. Unraveling the complexities of gut endocrinology Nature Clinical Practice Endocrinology & Metabolism April 2007 3(4)317
Drucker, D. J., Easley, C., and Kirkpatrick, P. Sitagliptin Nature Reviews Drug Discovery 2007 (6) 2; 109-110
Drucker D. J. The role of gut hormones in glucose homeostasis. J. Clin. Invest. 2007 117: 24-32
Sowden, G. L., Drucker, D. J., Weinshenker, D., Swoap, S. J.Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R962-70. Epub 2006 Oct 12
Hansotia, T., Maida, A., Flock, G., Yamada, Y., Tsukiyama, K., Seino, S., and Drucker, D. J. Extrapancreatic incretin receptors modulate glucose homeostasis and energy expenditure J Clin Invest 2007 January 2; 117(1): 143–15
2006
Drucker, D. J. and Nauck, M. A. The incretin system: glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes Lancet 2006 368: 1696-705
Yusta, B., Baggio, L. L., Estall, J. E., Koehler, J. A., Holland, D. P., Li, H., Pipeleers, D., Ling, Z., and Drucker, D. J. GLP-1 receptor activation improves b-cell function and survival following induction of endoplasmic reticulum stress Cell Metabolism 2006 Nov;4(5):391-406
Drucker, D. J. Enhancing the Action of Incretin Hormones: A New Whey Forward? Endocrinology Vol. 147, No. 7 3171-3172
Estall, J. L., and Drucker, D. J. Glucagon and glucagon-like Peptide receptors as drug targets. Curr Pharm Des. 2006;12(14):1731-50
Baggio, L. L., Holland, D., Wither, J., and Drucker D. J. Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-Exendin) transgenic mice Diabetes 2006 Jun;55 (6): 1562-70.
Cani, P. D., Knauf, C., Iglesias, M. A., Drucker, D. J., Delzenne, N. M., and Burcelin, R. Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor Diabetes 2006 55: 1484-1490
Estall, J. L.& Drucker, D. J. Glucagon-Like Peptide-2.Annu Rev Nutr. 2006 2006;26:391-411
Koehler, J. A, and Drucker, D. J. Activation of GLP-1 receptor signaling does not modify the growth or apoptosis of human pancreatic cancer cells Diabetes 2006 55: 1369-1379
Drucker, D. J. The biology of incretin hormones. Cell Metab. 2006 Mar;3(3):153-65. Review
Riddle, M. C., Drucker D. J. Emerging therapies mimicking the effects of amylin and glucagon-like Peptide 1. Diabetes Care. 2006 Feb;29(2):435-49
Baggio, L. L. and Drucker, D. J. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annu Rev Med. 2006; 57:265-81
Drucker, D. J. The evidence for achieving glycemic control with incretin mimetics. Diabetes Educ. 2006 Mar-Apr;32(2 Suppl):72S-81S.
Drucker, D. J. Incretin-based therapies: a clinical need filled by unique metabolic effects. Diabetes Educ. 2006 Mar-Apr;32(2 Suppl):65S-71
2005
Knauf, C., Cani, P. D., Perrin, C., Iglesias, M. A., Maury, J.-F., Bernard, E., Benhamed, F., Gremeaux, T., Drucker, D. J., Kahn, C. R., Girard, J., Tanti, J.-F., Delzenne, N. M., Postic, C., and Burcelin, R. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage J. Clin. Invest. 2005;115 3554-3563
Sinclair, E. M. and Drucker, D. J. Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential Physiology, Oct 2005; 20: 357 - 365
Talsania T., Anini Y., Siu S, Drucker D. J., Brubaker P.L. Peripheral Exendin-4 and Peptide YY3-36 Synergistically Reduce Food Intake through Different Mechanisms in Mice. Endocrinology. 2005 Sep;146(9):3748-56. Epub 2005 Jun 2.
Shin, E. D., Estall, J. L., Izzo, A., Drucker, D. J., and Brubaker, P. L. Mucosal Adaptation to Enteral Nutrients is Dependent on the Physiologic Actions of Glucagon-Like Peptide-2 in Mice. Gastroenterology. 2005 May;128(5):1340-53.
Schonhoff, S., Baggio, L., Ratineau, C., . Ray, S. K., Lindner, J., Magnuson, M.A., . Drucker, D. J., and Leiter, A. B. Energy Homeostasis and Gastrointestinal Endocrine Differentiation Do Not Require the Anorectic Hormone Peptide YY Mol. Cell. Biol. 2005 25: 4189-4199.
Estall, J. L., Koehler, J. A., Yusta, B., and Drucker, D. J. The GLP-2R C-terminus modulates beta-arrestin-2 association, but is dispensable for ligand-induced desensitization, endocytosis and G-protein-dependent effector activation J. Biol. Chem., Apr 2005 Jun 10;280(23):22124-34. Epub 2005 Apr 6
Hansotia, T., Drucker, D. J. GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice. Regul Pept. 2005 Jun 15;128(2):125-34
Maziarz M., Chung C., Drucker D.J., Emili A Integrating global proteomic and genomic expression profiles generated from islet α cells: Opportunities and challenges to deriving reliable biological inferences. Mol Cell Proteomics. 2005 Apr;4(4):458-474
Sinclair, E. M., and Drucker, D. J. Glucagon-like peptide-1 receptor agonist and DPP-IV inhibitors: new therapeutic agents for the treatment of type 2 diabetes. Current Opinion in Endocrinology and Metabolism 2005 12:146-151
Li, Y., Cao, X., Li, L.-X., Brubaker, P.L., Edlund, H., and Drucker, D.J. ß-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1. Diabetes 2005 54: 482-491
Reimann F., Maziarz M., Flock G., Habib A.M., Drucker D.J., Gribble F.M. Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line. J Physiol. 2005 Feb 15;563(Pt 1):161-75
Koehler, J., Yusta, B., and Drucker, D. J. The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways Mol Endocrinol. 2005 Feb;19(2):459-73
Estall, J. L. Drucker, D. J. Tales beyond the Crypt: Glucagon-Like Peptide-2 and Cytoprotection in the Intestinal Mucosa. Endocrinology. 2005 Jan; 146(1): 19-21
Flock, G., Cao, X., and Drucker, D. J. Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells Endocrinology 2005 146: 441-449
Lachey, J. L., D'Alessio, D. A., Rinaman, L., Elmquist, J. K., Drucker, D. J., Seeley, R. J. The role of central GLP-1 in mediating the effects of visceral illness: Differential effects in rats and mice Endocrinology 2005 146: 458-462
2004
Baggio L.L., Kim J.G., Drucker D.J. Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R-Dependent Glucose Homeostasis In Vivo. Diabetes. 2004 Dec;53 Suppl 3:S205-14
Baggio, L. L., and Drucker, D. J. Glucagon-like peptide-1 and glucagon-like peptide-2. Best Pract Res Clin Endocrinol Metab. 2004 Dec;18(4):531-54.
Baggio, L.L., Huang Q, Brown T. J, Drucker DJ. A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis Diabetes 2004 53: 2492-2500
Baggio L. L., Huang Q, Brown T. J, Drucker DJ. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology. 2004 Aug;127(2):546-58
Estall, J. L., Yusta, B., and Drucker, D. J. Lipid Raft-dependent GLP-2 Receptor Trafficking Occurs Independently of Agonist-induced Desensitization. Mol Biol Cell. 2004 Aug;15(8):3673-87
Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A., Yamada, Y., Tsukiyama, K., Seino, Y., Holst, J. J., Schuit, F., and Drucker, D. J. Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors Diabetes 2004 53: 1326-1335
Preitner, F., Ibberson, M., Franklin, I., Binnert, C., Pende, M., Gjinovci, A., Hansotia, T., Drucker, D. J., Wollheim, C., Burcelin, R., Thorens, B. Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors J Clin Invest 2004 113:635-645
Lovshin J.A., Huang Q., Seaberg R., Brubaker P.L., Drucker D.J. Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells. Endocrinology. 2004 Jul;145(7):3495-506.
Brubaker, P. L., Drucker DJ Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology. 2004 Jun;145(6):2653-9
2003
Estall, J. L., Drucker, D. J. Dual Regulation of Cell Proliferation and Survival via Activation of Glucagon-Like Peptide-2 Receptor Signaling. J Nutr. 2003 Nov;133(11):3708-11
Boushey, R. P., Abadir, A., Flamez, D., Baggio, L. L., Li, Y., Berger, V., Marshall, B. A., Finegood, D., Wang, T. C., Schuit, F., and Drucker, D. J. Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene Gastroenterology 2003 125:1164-174
Drucker, D. J.Enhancing Incretin Action for the Treatment of Type 2 Diabetes Diabetes Care 2003 26: 2929-2940
Walsh NA, Yusta B,
DaCambra MP, Anini Y, Drucker DJ, Brubaker PL Glucagon-like
Peptide-2 receptor activation in the rat intestinal mucosa. Endocrinology. 2003
Oct;144(10):4385-92. Epub 2003 Jul 03
During M.J., Cao L, Zuzga D.S.,
Francis J.S., Fitzsimons H.L., Jiao X., Bland R.J., Klugmann M., Banks W.A., Drucker
DJ, Haile CN Glucagon-like
peptide-1 receptor is involved in learning and neuroprotection. Nat
Med. 2003 Sep;9(9):1173-1179. Epub 2003 Aug 17
Gros, R., You, X., Baggio, L.
L., Kabir, M. G., Sadi, A-M., Mungrue,
Cao X, Flock G, Choi C, Irwin DM, Drucker DJ. Aberrant Regulation of Human Intestinal Proglucagon Gene Expression in the NCI-H716 Cell Line. Endocrinology. 2003 May;144(5):2025-33
Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK. Glucagon-Like Peptide-1-Responsive Catecholamine Neurons in the Area Postrema Link Peripheral Glucagon-Like Peptide-1 with Central Autonomic Control Sites. J Neurosci. 2003 Apr 1;23(7):2939-2946
Mayo, K. E., Miller, L. J., Bataille,
D., Dalle, S., Göke, B., Thorens, B., and Drucker,
D. J.
Kim, J.-G., Baggio, L.L., Bridon, D.P., Castaigne, J.-P., Robitaille, M.F., Jette, L., Benquet, C., and Drucker, D. J. Development and characterization of a GLP-1-albumin conjugate which retains the ability to activate the GLP-1 receptor in vivo. Diabetes 2003 52(3):751-9
Drucker, D. J. Glucagon-like peptides: Regulators of cell proliferation and apoptosis Mol Endocrinol 2003 17(2)161-171
DeLeon, D. D., Deng, S., Madani, R., Ahima, R., Drucker, D.J., Stoffers, D. A. Role of Endogenous Glucagon-Like Peptide-1 (GLP-1) in Islet Regeneration after Partial Pancreatectomy Diabetes 2003 Feb;52(2):365-371.
Trinh,
K.Y.T., Zhang, K., Hossain, M., Brubaker, P. L., and Drucker, D. J. Pax-6
activates endogenous proglucagon gene expression in the rodent gastrointestinal
epithelium Diabetes 2003 Feb;52(2):425-33.
Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker, D. J. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem. 2003 Jan 3;278(1):471-8
2002
Flock, G., and Drucker, D. J. Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine. Mol Endocrinol. 2002 Oct;16(10):2349-59.
Brubaker, P.L., and Drucker, D. J. Structure Function of the Glucagon Receptor Family of G Protein Coupled Receptors: The Glucagon, GIP, GLP-1, and GLP-2 Receptors. Receptors and Channels 2002 8:179-188
Adatia, FA, Baggio, LL, Xiao, Q, Drucker DJ, and Brubaker PL. Cellular specificity of proexendin-4 processing in Mammalian cells in vitro and in vivo. Endocrinology. 2002 Sep;143(9):3464-71
Brubaker PL, Drucker DJ, Asa SL, Swallow C, Redston M, Greenberg GR Prolonged Gastrointestinal Transit in a Patient with a Glucagon-Like Peptide (GLP)-1- and -2-Producing Neuroendocrine Tumor. J Clin Endocrinol Metab. 2002 Jul;87(7):3078-83
Yamamoto, H., Lee, C. E., Marcus, J. N., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L., Saper, C. B. Drucker, D. J., and Elmquist, J. K. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons J. Clin. Invest. 2002;110 43-52
Liu Y, Shen W, Brubaker PL, Kaestner KH, Drucker DJFoxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. Biochem J. 2002 Sep 1;366(Pt 2):633-41Yusta B, Estall J, Drucker DJ. GLP-2 receptor activation engages Bad and glycogen synthase kinase 3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase. J Biol Chem. 2002 Jul 12;277(28):24896-906
Drucker, D. J. Gut adaptation and the glucagon-like peptides. Gut. 2002 Mar;50(3):428-35
Drucker, D. J. Biological Actions and Therapeutic Potential of the Glucagon-like Peptides Gastroenterology 2002;122 531-544
Nian, M., Irwin, D.M. , Drucker, D. J., Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression. Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R173-R183
2001
Burcelin, R., Da Cost, A., Drucker,
D., and Thorens, B. Glucose Competence of the Hepatoportal Vein Sensor
Requires the Presence of an Activated Glucagon-Like Peptide-1 Receptor. Diabetes.
2001 Aug;50(8):1720-8.
Drucker, D. J. Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes. Curr Pharm Des. 2001 Sep 11;7(14):1399-412.
Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC Glucagon-like peptide 1 receptor
signaling influences topography of islet cells in mice. Virchows Arch 2001
Apr;438(4):382-7
Lovshin J, Estall J, Yusta B, Brown TJ, Drucker D.J. Glucagon-like peptide-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling. J Biol. Chem. 2001 Vol. 276, Issue 24, 21489-21499, June 15, 2001
Lefebvre D.L., Bai Y., Shahmolky N., Sharma M., Poon R., Drucker D.J., Rosen C.F. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. Biochem J 2001 Apr 15;355(Pt 2):297-305
Drucker, D. J. Glucagon-like
peptide 2. J Clin Endocrinol
Metab. 2001 Apr;86(4):1759-64.
Boushey, R. P., Yusta, B., and Drucker, D.J. Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor. Cancer Res. 2001 Jan 15;61(2):687-93
Drucker, D.J. The glucagon-like peptides Endocrinology 2001 142:521-527,
2000
Lovshin J, Yusta B, Iliopoulos I, Migirdicyan A, Dableh L, Brubaker PL, Drucker DJ Ontogeny of the glucagon-like peptide-2 receptor axis in the developing rat intestine Endocrinology 2000;141(11):4194-201
Baggio, L., Kieffer, T.J., and Drucker, D.J. GLP-1 but not GIP regulates fasting glycemia and non-enteral glucose clearance in mice Endocrinology 2000 Oct;141(10):3703-9
Yusta, B., Huang, L., Munroe, D., Wolff, G., Fantaske, G., Demchyshyn, L., Asa, S.L., and Drucker, D.J. Enteroendocrine Localization of GLP-2 Receptor Expression in Humans and Rodents Gastroenterology 2000 119: 744-755
Scrocchi, L.A., Hill, M.E., Saleh, J., Perkins, B., and Drucker, D.J. Elimination of GLP-1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action Diabetes 2000 49:1552-1560
Baggio, L., Adatia, F., Bock, T., Brubaker, P.L., Drucker, D.J Sustained expression of exendin-4 does not perturb glucose homeostasis, β cell mass or food intake in metallothionein-preproexendin transgenic mice J. Biol. Chem. 2000 275: 34471-34477
Bernardo Yusta, Robin P. Boushey, and Daniel J. Drucker The Glucagon-like Peptide-2 Receptor Mediates Direct Inhibition of Cellular Apoptosis via a cAMP-dependent Protein Kinase-independent Pathway J. Biol. Chem. 2000 275: 35345-35352.
DaCambra, M.P. Yusta,B., Sumner-Smith,M., Crivici, A., Brubaker, P.L., Drucker, D.J. Structural determinants for activity of Glucagon-like peptide-2. Biochemistry 2000 39: 8888 - 8894
Elias, C.F., Kelly, J.F., Lee, C.E., Ahima, R.S., Drucker, D.J., Saper, C.B., and Elmquist, J.K. Chemical characterization of leptin-activated neurons in the rat brain Journal of Comparative Neurology 2000 43:261-281
Lovshin J, Drucker DJ. New frontiers in the biology of GLP-2. Regul Pept. 2000 Jun 30;90(1-3):27-32
Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 Proc Natl Acad Sci U S A 2000 97(12):6874-6879
Xiao Q, Boushey RP, Cino M, Drucker DJ, Brubaker PL Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease. 1: Am J Physiol Regul Integr Comp Physiol 2000 Apr;278(4):R1057-63
MacLusky, N.J., Cook, S., Scrocchi, L.A., Shin, J., Kim, J., Vaccarino, F., Asa, S.L. and Drucker, D.J. Neuroendocrine function in mice with complete disruption of GLP-1 receptor signaling Endocrinology 2000 141:752-62.
1999
Drucker, D.J., DeForest, L., Yusta, B., Boushey, R.P. and Brubaker, P.L. Enhancement of intestinal epithelial repair by h[Gly2]-GLP-2 in a murine model of ulcerative colitis 1999 Am J Physiol 276:G79-G91
Munroe, D.G. Gupta, A.K., Kooshesh,P., Vyas, T.B., Rizkalla, G., Wang,H., Demchyshyn,L., Kamboj, R.K., McCallum, K., Sumner-Smith, M., Drucker, D.J., and Crivici, A. Prototypic G protein coupled receptor for the intestinotrophic factor glucagon-like peptide 2 1999 Proc. Natl. Acad. Sci (USA) 96:1569-1573
Kaestner, K.H., Katz, K., Liu, Y., Drucker, D.J. and Schutz, G. Inactivation of the winged helix transcription factor HNF3a affects glucose homeostasis and islet glucagon gene expression in vivo 1999 Genes & Development 13:495-504
Trinh K.Y., Jin, T., and Drucker, D.J. Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3 1999 J. Biol.Chem. 274:6011-6019
Drucker D. Glucagon-like peptide 2 1999 Trends in Endocrinology and Metabolism 10:153-156
Xiao, Q., Boushey, R.P., Drucker, D.J., and Brubaker, P.L. Secretion of the intestinotropic hormone glucagon-like peptide-2 is differentially regulated by nutrients in humans 1999 Gastroenterology 17:99-105
Hill, F.M., Asa, S.L., and Drucker, D.J. Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription 1999 Mol Endocrinol 13(9):1474-86
Drucker DJ, Boushey RP, Wang F, Hill ME, Brubaker PL, Yusta B Biologic properties and therapeutic potential of glucagon-like peptide-2 1999 J Parenter Enteral Nutr 23:S98-100
Daisy Flamez, Patrick Gilon, Karen Moens, An Van Breusegem, Dominique Delmeire, Louise A. Scrocchi, Jean-Claude Henquin, Daniel J. Drucker, and Frans Schuit Altered cAMP and Ca2+ signaling in mouse pancreatic islets with GLP-1 receptor null phenotype 1999 Diabetes 48:1979-1986
Yusta, B., Somwar, R., Wang, F., Munroe, D., Grinstein, S., Klip, A., and Drucker, D.J. Identification of GLP-2 activated signaling pathways in BHK fibroblasts expressing the rat GLP-2 receptor 1999 J. Biol. Chem. 274:30459-30467.
Boushey, R.P. Yusta, B., and Drucker, D. J. Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis 1999 Am J Physiol 277: E937-E947
Nian, M., Drucker, D.J., Irwin D. Divergent regulation of human and rat proglucagon gene promoters in vivo. 1999 Am J Physiol 277:G829-37
1998
Drucker D.J. The glucagon-like peptides. Diabetes 1998 47:159-169
Flamez, D., Breusegem, A.V., Scrocchi, L.A., Quartier, E., Pipeleers, D., Drucker, D.J., Schuit, F. Mouse pancreatic ß cells exhibit preserved glucose competence after disruption of the GLP-1 Receptor gene 1998 Diabetes 47: 646-652
Scrocchi, L.A., Marshall, B.A., Cook, S.M., Brubaker, P.L., and Drucker, D.J. Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling 1998 Diabetes 47: 632-639
Scrocchi, L.A. and Drucker D.J. Effects of aging and a high fat diet on body weight and glucose tolerance in GLP-1R-/- mice 1998 Endocrinology 139:3127-32
Pederson,R.A., Satkunarajah,M. McIntosh,C.H.S., Scrocchi,L.A., Flamez,D., Schuit,F., Drucker, D.J. and Wheeler, M.B. Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice 1998 Diabetes 47:1046-52.
Brubaker, P.L., Schloos, J., and Drucker, D.J. Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line 1998 Endocrinology 139:4108-4114
Serre,V., Dolci,W., Scrocchi, L.A., Drucker, D.J., Efrat,S., and Thorens, B. Exendin-(9-39) as an inverse agonist of the GLP-1 receptor. Implications for basal intracellular cAMP levels and ß cell glucose competence 1998 Endocrinology 139(11):4448-54
1997
Jin T., Trinh, D.K.Y., Wang, F., and Drucker, D.J. The Caudal homeobox gene cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells Mol Endocrinol 1997 11:203-209
Chen E., and Drucker, D.J. Tissue-specific expression of mRNAs with different open reading frames that encode proglucagon -derived peptides and exendin 4 in the lizard J. Biol. Chem. 1997 272:4108-4115
Tsai C.-H., Hill, M., and Drucker, D.J. Biological determinants of intestinotrophic properties of GLP-2 in vivo Am. J. Physiol. 1997 272:G662-G668
Brubaker, P.L. Izzo, A., Hill, M., and Drucker, D.J. Intestinal function in mice with small bowel growth induced by glucagon-like peptide 2. Am. J. Physiol.1997 272: E1050 - E1058
Tsai A., Hill, M., Asa, S.L., Brubaker, P.L., and Drucker, D.J. Intestinal growth-promoting properties of glucagon-like peptide 2 in mice. Am. J. Physiol. 1997 G662-G668
Brubaker PL, Crivici A, Izzo A, Ehrlich P, Tsai CH, Drucker DJ. Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2. Endocrinology. 1997 Nov;138(11):4837-43
Drucker D.J., Shi, Q., Crivici, A., Sumner-Smith, M., Tavares, W., Hill, M. DeForest, L., Cooper, S., and Brubaker, P.L. Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV Nature Biotechnology 1997 15:673-677
Drucker D.J. Intestinal growth factors. Am. J. Physiol. 1997 273:G3-G6
Fischer K.D., Dhanvantari, S., Drucker, D.J. and Brubaker, P.L. Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats Am. J. Physiol. 1997 273:E815-E820
Drucker D. J., DeForest, L., and Brubaker, P.L. Region-specific differences in the biological activity of intestinal growth factors administered alone or in combination with h[Gly2]-GLP-2 Am. J. Physiol. 1997 273:G1252-G1262
Scrocchi L.A., Brown, T.J., and Drucker, D.J. Leptin sensitivity in non-obese GLP-1 receptor-/- mice Diabetes 1997 46: 2029-2034
1996
Scrocchi, L.S., Brown,T.J., MacLusky,N., Brubaker, P.L., Auerbach,A.B., Joyner, A.L. and Drucker, D.J. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene Nat Med 1996 Nov;2(11):1254-8.
Jin T., and Drucker D.J.Activation of proglucagon gene transcription through a novel G1 promoter element by the caudal-related homeobox protein cdx-3 Mol Cell Biol 1996 16: 19-28
Slingerland J.M., Petrocelli, T., Poon, R., Drucker D.J. and Rosen, C.F. UVB Radiation mediates S phase checkpoint via induction of p21 Cip/Waf1 Oncogene 1996 12:1387-1396
Wang M., and Drucker D.J. Activation of amylin gene transcription by the LIM domain homeobox gene isl-1 Mol Endo 1996 10:243-251
Asa S.L., Lee, Y.C., and Drucker, D.J. Development of colonic and pancreatic endocrine tumors in mice expressing a glucagon-SV40 T antigen transgene Virchows Archives 1996 427:595-606
Shi Z.Q., Rastogi, K.S., Lekas, M., Efendic, S., Drucker, D.J., and Vranic, M. Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats Endocrinology 1996 137:3193-3199
Drucker D.J., Ehrlich, P., Asa, S.L., Brubaker, P.L. Induction of epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. 1996 93:7911-7916
Lu F., Jin,T., and Drucker, D.J. Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line. Endocrinology 1996 137:3710-3716.
1995
Rosen C.F., Chang, R., and Drucker D.J.. Identification of novel UVB-induced genes in rat keratinocytes. Am. J. Physiol 1995 268:C846-C855
Wang M., and Drucker D.J. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription J. Biol. Chem 1995 270:12646-12652
Jin T., and Drucker D.J. Gene transfer and EMSA analyses identify multiple cis-acting DNA sequences and DNA-protein complexes important for intestinal-specific proglucagon gene transcription Mol Endo 1995 9:1306-1320
The publications listed above are provided for information and use for Drucker lab members. Third parties wishing to obtain reprints should, where appropriate, contact the specific Journal.