The function of GLP-2 was unrecognized for many years. The story starts with the observation that several human subjects with glucagonomas exhibit small bowel growth, as summarized in GLP-2 and Human Tumors. In 1996 GLP-2 administration in mice was shown to markedly increase small bowel growth in only a few days, principally due to hyperplasia of the villus epithelium
To understand the molecular basis of GLP-2 action, review the data on the GLP-2 receptor.
For an overview of GLP-2 synthesis and secretion, see GLP-2 secretion and metabolism.
To review the potential therapeutic efficacy of GLP-2, see GLP-2 and intestinal disease
To review experiments examining the essential physiological actions of GLP-2, See Essential GLP-2 action: Studies with antagonists