Drucker Lab citations  https://scholar.google.ca/citations?user=xmFOoRYAAAAJ&hl=en



Akindehin S, Liskiewicz A, Liskiewicz D, Bernecker M, Garcia-Caceres C, Drucker D.J, Finan B, Grandl G, Gutgesell R, Hofmann S.M, Khalil A, Liu X, Cota P, Bakhti M, Czarnecki O, Bastidas-Ponce A, Lickert H, Kang L, Maity G, Novikoff A, Parlee S, Pathak E, Schriever S.C, Sterr M, Ussar S, Zhang Q, DiMarchi R, Tschöp M.H, Pfluger P.T, Douros J.D, Müller T.D. Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice Mol Metab. 2024 Mar 14:101915. doi: 10.1016/j.molmet.2024.101915

Greiner T.U, Koh A, Peris E, Bergentall M, Johansson M.E.V, Hansson G.C, Drucker D.J, Bäckhed F. GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota Mol Metab. 2024 Mar 21:101924. doi: 10.1016/j.molmet.2024.101924

Wang, M-Y., Zhang, Z., Zhao, S., Onodera, T., Sun, X., Zhu, Q., Li, C., Li, N., Chen, S., Marciano, D.K., Gordillo, R., Drucker, D.J., Scherer, P. E. Down-regulation of kidney glucagon receptor, essential for normal renal function and systemic homeostasis, contributes to the development of chronic kidney disease Cell Metabolism 2024  https://doi.org/10.1016/j.cmet.2023.12.024

Drucker D. J. The GLP-1 journey: from discovery science to therapeutic impact J Clin Invest. 2024 Jan 16;134(2):e175634

Drucker, D. J. Prevention of cardiorenal complications in people with diabetes and obesity Cell Metabolism 2024 https://doi.org/10.1016/j.cmet.2023.12.018

Wong, C.K., Maclean, B. A., Baggio, L. L., Koehler, J. A., Hammoud, R., Rittig, N., Yabut, J. M., Seeley, R. J., Brown, T. K., Drucker, D. J. Central glucagon-like peptide 1 receptor activation inhibits Toll like receptor -induced inflammationCell Metabolism 2024 36(1) https://doi.org/10.1016/j.cmet.2023.11.009

Sourris K.C., Ding Y, Maxwell S.S., Al-sharea A, Kantharidis P, Mohan M, Rosado C.J., Penfold S.A., Haase C, Xu Y, Forbes J.M., Crawford S, Ramm G, Harcourt B.E., Jandeleit-Dahm K, Advani A, Murphy A.J., Timmermann D.B., Karihaloo A, Knudsen L.B., El-Osta A, Drucker D.J., Cooper M.E., Coughlan M.T.. GLP-1 receptor signaling modifies the extent of diabetic kidney disease through dampening RAGE-induced inflammation. Kidney International 2023 https://www.kidney-international.org/article/S0085-2538(23)00756-1/fulltext



Le, T.D.V., Fathi, P.,  Watters,A.B., Ellis, B.J.,Bozadjieva-Kramer, N., Perez, M.B., Sullivan, A.I., Rose, J.P., Baggio, L.L., Koehler J, Brown J.L., Bales M.B, Nwaba K.G., Campbell J.E., Drucker D.J, Potthoff MJ, Seeley RJ, Ayala JE Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets Molecular Metabolism 2023 https://doi.org/10.1016/j.molmet.2023.101718

Ussher, J.R., & Drucker D. J. Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action Nature Reviews Cardiology 2023 https://doi.org/10.1038/s41569-023-00849-3

Drucker, D. J. and Holst J. J. The expanding incretin universe: from basic biology to clinical translation  Diabetologia 2023 https://doi.org/10.1007/s00125-023-05906-7

Castle A.R., Kang S.G., Eskandari-Sedighi G., Wohlgemuth S., Nguyen M.A., Drucker D.J., Mulvihill E.E., Westaway D. Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein. 2023 Jan 3;120(1):e2209815120. doi: 10.1073/pnas.2209815120


Hammoud, R., & Drucker, D.J. Beyond the pancreas: contrasting cardiometabolic actions of GIP and GLP1 Nat Rev Endocrinol. 2022 Dec 12. doi: 10.1038/s41574-022-00783-3.


McLean, B.A, Wong, C. K., Kabir, M. G., Drucker D. J. Glucagon-Like Peptide-1 Receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction Molecular Metabolism 2022 https://doi.org/10.1016/j.molmet.2022.101641

Zimmermann, T., Thomas, L., Baader-Pagler, T., Haebel, P.,   Simon, E., Reindl, W., Bajrami, B., Rist, W., Uphues, I., Drucker, D. J., Klein, H., Santhanam, R., Hamprecht, D., Neubauer, H., Augustin. R. BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy Molecular Metabolism 2022 doi.org/10.1016/j.molmet.2022.101633

Pujadas, G., Baggio, L.L., Kaur, K.D., McLean, B.A., Cao, X., Drucker, D. J. Genetic disruption of the Gipr in Apoe-/- mice promotes atherosclerosis Molecular Metabolism 2022 https://doi.org/10.1016/j.molmet.2022.101586

Wong, C.K., Yusta, B., Koehler, J. A., Baggio, L.L., McLean, B.A., Matthews, D., Seeley, R.J., Drucker D.J. Divergent roles for the gut intraepithelial lymphocyte GLP-1 receptor in control ofmetabolism, microbiota, and T cell-induced inflammation Cell Metabolism 2022 34; https://doi.org/10.1016/j.cmet.2022.08.003

Quarta C., Stemmer K., Novikoff A., Yang B., Klingelhuber F., Harger A., Bakhti M., Bastidas-Ponce A., Baugé E., Campbell J.E., Capozzi M., Clemmensen C., Collden G., Cota P., Douros J., Drucker D.J., DuBois B., Feuchtinger A., Garcia-Caceres C., Grandl G., Hennuyer N., Herzig S., Hofmann S.M., Knerr P., Kulaj K., Lalloyer E., Lickert H., Liskiewicz A., Liskiewicz D., Maity G., Perez-Tilve D., Prakash S., Sanchez Garrido M., Zhang Q., Staels B., Krahmer N., DiMarchi R.D., Tschöp M.H., Finan B., Müller T.D. GLP-1-mediated delivery of the PPAR??/?? dual-agonist Tesaglitazar improves obesity and glucose metabolism in mice Nature Metabolism 2022 https://doi.org/10.1038/s42255-022-00617-6

Yabut, J., Drucker D.J. Glucagon-like peptide-1 receptor-based therapeutics for metabolic liver disease Endocrine Reviews 2022 doi/10.1210/endrev/bnac018/6652476

Drucker D.J. Bernard Zinman: A Canadian Clinician Scientist Changing the Management of Diabetes Diabetes Care 2022;45(8):1709–1714

Chen, M.E., Naeini, S. M., Shrikrishnaraj, A., Drucker D.J., Fesler, Z., Brubaker, P.L. Glucagon-like peptide-2 stimulates S-phase entry of intestinal Lgr5+ stem cells Cellular and Molecular Gastroenterology and Hepatology https://doi.org/10.1016/j.jcmgh.2022.02.011

Campbell JE, Beaudry JL, Svendsen B, Baggio LL, Gordon AN, Ussher JR, Wong CK, Gribble FM, D'Alessio DA, Reimann F, Drucker DJ. The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue Diabetes. 2022 Feb 22:db211166. doi: 10.2337/db21-1166.

Drucker, D.J. GLP-1 physiology informs the pharmacotherapy of obesity Mol Metabolism 2022 2022 Mar;57:101351. doi: 10.1016/j.molmet.2021.101351



Cherney, D. C., Udell, J., Drucker D. J. Cardiorenal mechanisms of action of glucagon-like-peptide-1 receptor agonists and sodium–glucose cotransporter 2 inhibitors MED 2021 2 (11), 1203-1230

McLean, B. A., Wong, C.K., Kaur, K.D., Seeley, R.J., Drucker, D. J. Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic vs. hepatic actions of semaglutide JCI Insight 2021 6(22) Oct 21;e153732

Overgaard, R.V., .Hertz, C. L., Ingwersen, S. H., Navarria, A., Drucker, D.J. Levels of circulating semaglutide determine reductions in HbA1c and body weight in people with type 2 diabetes Cell Reports Medicine 2021 Sept 3 https://doi.org/10.1016/j.xcrm.2021.100387

Heiss, C. N., Mannerås-Holm, L., Lee, Y. S., Serrano Lobo, J., Anna Håkansson, Seeley, R. J., Drucker, D. J., Bäckhed, F., Olofsson, L. E., The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1 receptor-dependent mechanism Cell Reports 2021 May 25;35(8):109163. doi: 10.1016/j.celrep.2021.109163

Kaur K.D., Wong CK, Baggio LL, Beaudry JL, Fuchs S, Panaro BL, Matthews D, Cao X, Drucker D.J. TCF7 is not essential for glucose homeostasis in mice Mol Metab. 2021 Mar 16:101213. doi: 10.1016/j.molmet.2021.101213

GIPR signaling in immune cells maintains metabolically beneficial type 2 immune responses in the white fat from obese mice Efimova, I., Steinberg, I., Zvibel, I., Neumann, A., Mantelmacher, D.F., Drucker, D. J., Sigal Fishman, S.,Varol, C. Frontiers Immunology February 2021 | https://doi.org/10.3389/fimmu.2021.643144

Zhang Q., Delessa C.T., Augustin R., Bakhti, M., Colldén, G.,  Drucker, D. J., Feuchtinger, A., Caceres, C. G., Grandl, G., Harger, A., Herzig, S., Hofmann, S., Holleman, C. L., Jastroch, M., Keipert, S., Kleinert, M., Knerr, P. J. Kulaj, K., Legutko, B., Lickert,  H., Liu, X., Luippold, G., Lutter, D., Malogajski, E., Medina, M. T., Mowery, S. A., Blutke, A., Perez-Tilve, D., Salinno, C., Sehrer, L., DiMarchi, R. D., Tschöp, M. H., Stemmer, K., Finan, B., Wolfrum, C., Müller, T. D., (2021) The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling. Cell metabolism (33) https://doi.org/10.1016/j.cmet.2021.01.015

Drucker D. J. Transforming type 1 diabetes: the next wave of innovation Diabetologia 2021 Feb 5 10.1007/s00125-021-05396-5

Drucker, D. J. Diabetes, Obesity, Metabolism, and SARS-CoV-2: The end of the beginning Cell Metabolism 2021 https://doi.org/10.1016/j.cmet.2021.01.016

McLean, B. A., Wong, C.-K., Campbell, J.E., Hodson, D.J, Trapp, S., Drucker, D.J. Revisiting the complexity of GLP-1 action-from sites of synthesis to receptor activation Endo Rev 2021 Mar 15;42(2):101-132




Sato, S., Shimizu, T., Fujita, H., Imai, Y., Drucker, D. J., Seino, Y., Yamada, Y. GLP-1 receptor signaling differentially modifies the outcomes of sterile vs. viral pulmonary inflammation in male mice Endocrinology. 2020 Dec 1;161(12):bqaa201.

Baggio, L.L., & Drucker D. J. Glucagon-like Peptide-1 Receptor co-agonists for the treatment of metabolic disease Mol Metabolism 2020 https://doi.org/10.1016/j.molmet.2020.101090

Baggio, L.L., Varin, E.M., Koehler, J.A., Cao, X., Lokhnygina, L., Stevens, S.R. , Holman, R. R., Drucker D.J.  Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans. Nat Commun 11, 3766 (2020) https://doi.org/10.1038/s41467-020-17556-z

Varin, E. M., Hanson,A.A., Beaudry, J. L.,, Nguyen, M.-A., Cao, X., Baggio, L. L., Mulvihill, E. E., Drucker, D. J., Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans JCI Insight 2020 https://doi.org/10.1172/jci.insight.140418.

Pujadas, G., Varin E.M., Baggio, L.L. Mulvihill, E.E., Bang, K.W.A., Koehler, J.A., Matthews, D., Drucker D.J. The gut hormone receptor GIPR links energy availability to control of hematopoiesis Molecular Metabolism 2020 doi.org/10.1016/j.molmet.2020.101008

Drucker D. J. Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications Endocr Rev. 2020 June 41(3). pii: bnaa011. doi: 10.1210/endrev/bnaa011

Panaro, B. L., Yusta, B., Matthews, D., Koehler, J. A., Song, Y., Sandoval, D. A., Drucker D. J. Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion Molecular Metabolism 2020 (37) July  https://doi.org/10.1016/j.molmet.2020.100990

Fuchs S, Yusta B, Baggio L. L, Varin E. M, Matthews D, Drucker D. J. Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice JCI Insight. 2020 Mar 19. pii: 136907. doi: 10.1172/jci.insight.13690

Lund, M.L, Sorrentino, G, Egerod, K.L, Kroone, C, Mortensen, B, Knop, F.K, Reimann, F, Gribble, F.M, Drucker, D.J, de Koning, E.J.P, Schoonjans, K., Bäckhed, F., Schwartz, T. W., and Petersen, N. L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling. Diabetes 2020:db190764

Helmstädter, J., Frenis, K., Filippou, K., Grill, A., Dib, M., Kalinovic, S., Pawelke, F., Kus, K., Kröller-Schön, S., Oelze, M., Chlopicki, S., Schuppan, D., Wenzel, P., Ruf, W., Drucker, D. J., Münzel, T., Daiber A., Steven, S. Cardiovascular protection by liraglutide in mice with experimental arterial hypertension is mediated by the endothelial GLP-1 receptor ATVB 2020 Jan;40(1):145-158

Filippidou, F. M., Kirsch, A. H., Thelen1 M.,Kétszeri, M., Artinger, K., Aringer, I.,Schabhüttl, C.,Mooslechner, A. A.,Frauscher, B., Pollheimer, M., Niedrist, T.,Meinitzer, A., Drucker, D. J., Pieber,T. R., Eller P., Rosenkranz, A.R.,  Heinemann, A., Eller, K. Glucagon like peptide-1 receptor agonism improves nephrotoxic serum nephritis by inhibiting T cell proliferation American J Pathology 2020 Feb;190(2):400-411



Drucker DJ Advances in oral peptide therapeutics Nat Rev Drug Discov (2019) doi:10.1038/s41573-019-0053-0

Beaudry, J. L., Drucker D. J. Proglucagon-Derived Peptides, GIP and Dipeptidyl Peptidase-4-Mechanisms of Action in Adipose Tissue Endocrinology 2020 https://doi.org/10.1210/endocr/bqz029

Deshmukh, A.S., Peijs L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjær, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z., Nielsen, S., Drucker, D. J., Mann, M.,  Scheele, C. Proteomics-based comparative mapping of the secretomes of human brown and white adipocytes reveals EPDR1 as a novel batokine Cell Metabolism 2019 Nov 5;30(5):963-975

Müller, T.D., Finan, B., Bloom, S. R.,  D’Alessio, D.,  Drucker, D. J. Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W.,  Meier, J. J.,  Nauck, M. A.,  Perez-Tilve, D.,  Pocai, A.,  Reimann, F., Sandoval, D. A., Schwartz, T. W., Seeley, R. J., Stemmer, K.,Tang-Christensen, M.,  Woods, S. C.,  DiMarchi, R. D., Tschöp, M. H. Glucagon-like Peptide-1 (GLP-1) Mol Metabolism 2019 Dec;30:72-130

Findeisen, M., Allen, T. L.,  Henstridge, D. C., Kammoun, H., Brandon, A. E., , Baggio, L. L.,   Pal, M.,  Cron, L.,  Estevez, E., Yang, C., Kowalski, G. M., O’Reilly, L.,  Egan, C.,  Sun, E., May Thai, L., Krippner, G., Adams, T. E., Lee, R. S.  Grötzinger, J.,  Risis, S., Kraakman, M. J., Mellet, N. A.,  Young, R. L., Cowley, M. A., Bruce, C. R., Meikle, P. J., Baldock, P. A., Biden, T. J., Cooney, G. J., , Keating, D. J., Drucker, D. J.,  Rose-John S., Febbraio, M. A. Treatment of type 2 diabetes with the designer cytokine IC7Fc Nature 2019 Oct;574(7776):63-68

Song, Y., Koehler, J. A., Baggio, L.L., Powers, A. C, Sandoval, D.A., Drucker D. J. Gut proglucagon-derived peptides are essential for regulating glucose homeostasis in mice Cell Met 2019 https://doi.org/10.1016/j.cmet.2019.08.009

Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, S-I., Mukouyama, H., Kishino, S., Li, X., Ichimura, A., Irie, J., Sugimoto, J., Mizutani, T., Sugawara, T., Miki, T., Ogawa, J., Drucker, D. J. Arita, M., Itoh, H., and Kimura, H. Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids Nature Communications 2019 10(1)4077 10.1038/s41467-019-11978-0

Beaudry, J. L.,. Kaur, K. D., Varin, E. M., Baggio, L. L.,  Cao, X., Mulvihill, E. E., Bates, H. E., Campbell, J. E., Drucker, D. J. Physiological roles of the GIP receptor in murine brown adipose tissue Molecular Metabolism 2019 (28) Oct 14-25

Yusta B, Matthews D, Koehler JA, Pujadas G, Kaur K, Drucker DJ Localization of Glucagon-like Peptide-2 Receptor Expression in the Mouse Endocrinology. Volume 160, Issue 8, August 2019, Pages 1950–1963.

Varin E.M., Mulvihill E.E., Baggio L.L., Koehler J.A., Cao X., Seeley R.J., Drucker D.J. Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action Cell Rep. 2019 Jun 11;27(11):3371-3384.e3

Drucker D. J. The discovery of GLP-2 and development of teduglutide for short bowel syndrome ACS Pharmacol. Transl. Sci., Just Accepted Manuscript DOI: 10.1021/acsptsci.9b00016

Beaudry, J.L., Kaur, K., Varin, E. M., Baggio, L. L., Cao, X., Mulvihill, E. E., Stern, J. H., Campbell, J. E., Scherer, P. E., Drucker, D. J. The Brown Adipose Tissue Glucagon Receptor is Functional But Not Essential for Control of Energy Homeostasis in Mice Molecular Metabolism 2019 https://doi.org/10.1016/j.molmet.2019.01.011

He, S., Kahles, F., Rattik, S., Nairz, M., McAlpine, C. S., Anzai, A., Selgrade, D., Fenn, A.M.,  Chan, C.T., Mindur, J. E., Valet, C., Poller, W., Hall, L., Rotllan, N., Iwamoto, Y., Wojtkiewicz, G.R., Weissleder, R., Libby, P., Fernández-Hernando, C., Drucker, D. J., Nahrendorf, M., Swirski, F. K. Gut intraepithelial T cells calibrate dietary metabolism and accelerate cardiovascular disease Nature 2019 Jan 30  10.1038/s41586-018-0849-9

Mantelmacher, F.D., Zvibel, I., Cohen, K., Epshtein, A., Pasmanik-Chor, M., Vogl, T., Kuperman, Y., Weiss, S., Drucker, D. J., Varol, C., and Fishman, S. (2019). An enteroendocrine-myeloid cell S100A8/A9 axis controls inflammation and body weight. Nature Metabolism 2019(1)58-69

Panaro, B. L., Coppage, A. L., Beaudry, J. L.,  Varin, E. M.,   Kaur, K., Lai, J. H.,  Wu, W.,  Liu, Y.,  Bachovchin, W. W., Drucker, D. J.  Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice Molecular Metabolism 2019 Jan;19:65-74

Varin, E. M., Mulvihill, E. E., Beaudry, J. L., Pujadas, G., Fuchs, S., Tanti, J.-F., Fazio, S., Kaur, K., Cao, X., Baggio, L. L., Matthews, D., Campbell, J. E., Drucker, D. J., Circulating levels of soluble dipeptidyl peptidase-4 are dissociated from inflammation and induced by enzymatic DPP4 inhibition Cell Metabolism 2018 https://doi.org/10.1016/j.cmet.2018.10.001


Svendsen, B., Larsen, O., Gabe, M. B. N., Christiansen, C. B., Rosenkilde, M. M., Drucker, D. J., Holst, J. J., Insulin secretion depends on intraislet glucagon signaling Cell Reports 2018 25(5)1127-1134

Kim T, Loyd C, Holleman C, Arble DM, Ottaway N, Chabenne J, Sandoval D, Drucker D.J., DiMarchi RD, Perez-Tilve D, & Habegger KM. Glucagon-receptor signaling enhances insulin sensitivity in rodents. Diabetes. 2018 Aug 27. pii: db180068. doi: 10.2337/db18-0068.

Drucker, D. J. The ascending GLP-1 road from clinical safety to reduction of cardiovascular complications Diabetes 2018 Sep;67(9):1710-1719

Patel, A., Yusta, B., Matthews, D., Charron M. J., Seeley, R. J., Drucker, D. J. GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr-/- mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy Molecular Metabolism2018 Oct;16:45-54

Kim, T.,  Nason, S.,  Holleman, C., Pepin, M.,  Wende, A.,  Steele, C.,  Young, M., Barnes, S., Drucker, D. J.,  DiMarchi, R., Perez-Tilve, D.,  Tschoep, M., & Habegger, K. M. Glucagon-receptor signaling regulates energy metabolism via hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21 Diabetes. 2018 Sep;67(9):1773-1782

Gloyn, A.M., Drucker, D. J. Precision medicine in the management of type 2 diabetes Lancet Diabetes & Endocrinology 2018 https://doi.org/10.1016/S2213-8587(18)30052-4

Drucker, D. J. Mechanisms of Action and Therapeutic Application of Glucagon-Like Peptide-1 Cell Metabolism 2018 27, Issue 4, 740–756

Baggio, L.L., Yusta, B.,  Mulvihill, E. E.,  Cao, X., Streutker, C. J., Butany, J.,  Cappola, T.P. Margulies, K. B.,  Drucker, D. J. GLP-1 receptor expression within the human heart Endocrinology (2018), en.2018-00004, https://doi.org/10.1210/en.2018-00004

Remm, F., Krankel, N., Lener, D., Drucker, D. J., Sopper, S., Brenner, C. Sitagliptin accelerates endothelial regeneration after vascular injury independent from GLP1 receptor signaling Stem Cells International, vol. 2018, Article ID 5284963, 11 pages, 2018. doi:10.1155/2018/5284963

Iwasaki, Y., Sendo, M.,  Dezaki, K.,  Hira,T.,  Sato, T.,  Nakata, M., Goswami, C., Aoki, R., Arai, T., Kumari, P., Hayakawa, M., Masuda, C., Okada, T., Hara, H., Drucker, D. J.,  Yamada, Y., Tokuda, M.,  Yada, T. GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose Nature Communications 9, 113(2018) doi:10.1038/s41467-017-02488-y


Jansson, J.-O., Palsdottir, V., Hägg, D. A., Schéle1, E., Dickson, S. L., Anesten, F., Bake1, T., Montelius, M., Bellman, J., Johansson, M. E., Cone, R. D., Drucker, D. J., Wu, J., Aleksic, B., Törnqvist, A. E., Sjögren, K., Gustafsson, J.-A., Windahl, S. H., Ohlsson, C. A body weight homeostat that regulates fat mass independently of leptin in rats and mice PNAS 2017 doi: 10.1073/pnas.171568711

Ussher, J. R., Campbell, J. E., Mulvihill, E. E., . Baggio, L. L., Bates, H. E., McLean, B. A.,  Gopal, K.,  Capozzi, M.,  Yusta, B.,   Cao, X., Ali, S.,  Kim, M., Kabir, M. G.,  Seino, Y.,  Suzuki, J.,  Drucker, D. J. Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes Following Experimental Myocardial Infarction Cell Metabolism 2018 27(2) 450-460


Drucker, D. J., Habener, J.F., Holst J.J. Discovery, characterization and clinical development of the glucagon-like peptides J Clin Invest 2017 127(12):4217–4227.

Lebrun, L.J., Kaatje Lenaerts, J., Kiers, D., Pais de Barros, J.-P., Le Guern,N.,  Plesnik, J., Thomas, C., Bourgeois, T.,  Dejong, C.H.C., Kox, M., Hundscheid, I.H.R., Khan, N.A., Mandard, S., Deckert, V., Pickkers, P., Drucker, D. J., Lagrost, L., Grober, J. Enteroendocrine cells sense LPS after gut barrier injury to enhance GLP-1 secretion Cell Reports Oct 31 2017: 21(5) 1160-1168

Baggio, L.L., Ussher, J.E., McLean, B.A., Cao, X., Kabir, M.G., Mulvihill, E.E., Mighiu, A., Zhang, H., Ludwig, A., Seeley, R.J.,  Heximer, S.P.,  Drucker, D.J. The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice Molecular Metabolism 2017 http://dx.doi.org/10.1016/j.molmet.2017.08.010

Nauck, M.A., Meier, J.J., Cavender, M.A.,  Abd El Aziz, M.,  Drucker, D. J. Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors Circulation. 2017;136:849-870

Lovshin, J.A.,  Rajasekeran, H., Lytvyn, Y.,  Lovblom, L.E.,  Khan, S., Alemu, R., Locke, A., Lai, V., He, H., Hittle, L., Wang, W., Drucker, D. J.,Cherney, D.Z.I. Dipeptidyl Peptidase-4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1a1-67 in Patients With Type 2 Diabetes Diabetes Care 2017;40:1–9 | https://doi.org/10.2337/dc17-0061

Wismann, P., Barkholt, P.,  Secher, T.,  Vrang, N., Hansen, H. B., Jeppesen, P. B.,  Baggio, L. L.,. Koehler, J. A., Drucker, D. J., Sandoval, D. A., Jelsing, J.  The endogenous preproglucagon system is not essential for gut growth homeostasis in mice Molecular Metabolism 2017 doi.org/10.1016/j.molmet.2017.04.007

Yusta, B., Matthews, D., Flock, G. B., Ussher, J.R., Lavoie, B., Mawe, G. M., Drucker, D. J. Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway Molecular Metabolism 2017  10.1016/j.molmet.2017.03.006

Chambers, A. P., Sorrell, J., Haller, A., Roelofs, K.,  Hutch, C., Kim, K-S., Gutierrez-Aguilar, R.,  Li, B., Drucker, D. J., . D’Alessio, D. A., Seeley, R. J. Sandoval, D. A. The role of pancreatic preproglucagon in glucose homeostasis in mice Cell Metabolism 2017 Apr 4;25(4):927-934

Panaro, B. L. Flock, G. B.,  Campbell, J. E., Beaudry, J. L.,  Cao, X.,   Drucker, D. J. β-Cell Inactivation of Gpr119 Unmasks Incretin-Dependence of GPR119-Mediated Glucoregulation Diabetes 2017 Jun; 66(6): 1626-1635

Lee, K., Koehler, J., Yusta, B., Bahrami, J., Matthews, D., Rafii, M., Penhcarz, P. B., Drucker D. J. Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport Mol Metabolism 6 (2017) 245-255

Burmeister1, M.A., Ayala, J.E., Smouse, H., Landivar-Rocha, A., Brown, J. D., Drucker, D. J., Stoffers, D. A., Sandoval, D. A., Seeley, R. J., Ayala, J. E. The Hypothalamic Glucagon-Like Peptide-1 (GLP-1) Receptor (GLP-1R) is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice Diabetes 2017 Feb;66(2):372-384 http://dx.doi.org/10.2337/db16-1102

Mulvihill, E. E., Varin, E. M., Gladanac, B., Campbell, J. E., Ussher, J. R., Baggio, L. L., Yusta. B., Ayala, J., Burmeister, M. A., Matthews, D., Bang, K. W. A., Ayala, J. E., Drucker D. J. Cellular sites and mechanisms linking reduction of dipeptidyl peptidase-4 activity to control of incretin hormone action and glucose homeostasis Cell Metabolism 2017 (25) 152-165




Pujadas, G., Drucker, D. J. Vascular biology of glucagon receptor superfamily peptides: complexity, controversy, and clinical relevance Endocrine Reviews 2016 37: 554–583

Drucker, D. J. Never waste a good crisis: Confronting reproducibility in translational research Cell Metabolism 2016 24(3) 348–360

Lynch, L., Hogan, A. E., Duquette, D., Lester, C., Banks, A., LeClair, K., Cohen, D. E., Ghosh, A., Lu, B., Corrigan, M., Stevanovic, D., a Maratos-Flier, E., Drucker, D. J., O’Shea, D., Brenner, M. iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy, Cell Metabolism (2016), 24(3) 510-519

Takashima,  S., Fujita, H.,  Fujishima, H.,  Shimizu, T.,  Sato, T., Morii, T., Tsukiyama, K.,  Narita, T., Takahashi, T., Drucker, D. J.,  Seino, Y., Yamada, Y.  Stromal cell–derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy Kidney International 2016 http://dx.doi.org/10.1016/j.kint.2016.06.012

Sánchez-Garrido, M.A., Habegger, K.M., Clemmensen, C., Holleman, C., Müller, T.D., Perez-Tilve, D., Li, P., Agrawal, A.S., Finan, B., Drucker, D.J., Tschöp, M.H., DiMarchi, R.D., and Kharitonenkov, A. Fibroblast Activation Protein (FAP) as a Novel Metabolic Target. Molecular Metabolism 2016. 10.1016/j.molmet.2016.07.003

Drucker, D. J. The Cardiovascular Biology of Glucagon-like Peptide-1 Cell Metabolism 2016 10.1016/j.cmet.2016.06.009

Arora, T., Wegmann, U., Bobhate, A., Lee, Y.S., Greiner, T.U., Drucker, D.J., Narbad, A., and Bäckhed, F. Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice. Molecular Metabolism. 2016 10.1016/j.molmet.2016.06.006

Mulvihill, E. E., Elodie M. Varin, E. M., Ussher, J. R., Campbell, J. E., Bang, K. W. A.,  Abdullah, T., Baggio, L. L., Drucker, D. J. Inhibition of Dipeptidyl Peptidase-4 impairs ventricular function and promotes cardiac fibrosis in high fat-fed diabetic mice Diabetes 2016 65:3 742-754

Campbell, J. E., Ussher, J. R., Mulvihill, E. E., Baggio, L. L.,  Kolic, J., Cao, X.,  Liu, Y., Lamont, B. J.,  Morii, T.,  Streutker, C.,  Tamarina, N., Philipson, L. H., Wrana, J. L., MacDonald, P. E., and Drucker, D. J. TCF1 links GIPR signaling to the control of beta cell function and survival Nature Medicine 2016 Jan;22(1):84-90.



Drucker, D. J. Evolving concepts and translational relevance of enteroendocrine cell biology J Clin Endocrinol Metab doi: 10.1210/jc.2015-3449

Oropeza, D., Jouvet, N., Budry, L., Campbell, J. E., Bouyakdan, K.,  Lacombe, J., Perron, G., Bergeron,V., Neuman, J. C., Brar, H. K., Fenske, R. J., Meunier, C., Sczelecki, S.,  Kimple, M. E., Drucker, D. J.,  Screaton, R. A., Poitout, V., Ferron, M., Alquier,T., and Estall, J. L. Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone Diabetes 2015;64:3798–3807


Claussnitzer, M., Dankel, S. N., Kim, K-H., Quon, G., Meuleman, W.,  Haugen, C., Glunk, V., Sousa, I. S., Beaudry, J. L., a Puviindran, V., Abdennur, N. A.,  Liu, J., Svensson, P.-A., Hsu, Y.-H., Drucker, D. J., Mellgren, G.,  Hui, C.-C., Hauner, H.,  Kellis, M. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans N Engl J Med. 2015 Sep 3;373(10):895-907

Gagnon, J., Baggio, L. L., Drucker, D. J., Brubaker, P. L. Ghrelin is a novel regulator of glucagon-like peptide-1 secretion Diabetes 2015 64(5):1513-21

Campbell, J. E., Drucker, D. J. Islet a cells and glucagon-critical regulators of energy homeostasis Nature Reviews Endocrinology 2015 Jun;11(6):329-338

Landgraf, D., Tsang, A. H., Leliavski, A.,Koch, C.E., Barclay, J. L., Drucker, D. J., Oster, H. Oxyntomodulin regulates resetting of the liver circadian clock by food eLife 2015;10.7554/eLife.06253

Koehler, J. K., Baggio, L. L., Yusta, B., Longuet, C., Rowland, K. J., Cao, X., Holland, D., Brubaker. P. L., and Drucker D. J. GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7 Cell Metabolism 2015 21;3:379–391

Yusta, B., Baggio, L. L., Koehler, J. A., Holland, D., Cao, X., Pinnell, L. J., Johnson-Henry, K. C., Yeung, W., Surette, M. G., Bang, K. W. A.A., Sherman, P. M., Drucker, D. J. GLP-1 receptor (GLP-1R) agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte (IEL) GLP-1R Diabetes 2015 64:2537-2549

Harasta, A.,Power, J.,  Jonquieres, G.,  Karl, T., Drucker, D. J.  Housley, G., Schneider, M., and Klugmann, M. Septal glucagon-like peptide 1 receptor expression determines suppression of cocaine-induced behaviour Neuropsychopharmacology  2015 Jul;40(8):1969-78

Takaia, S.,  Yasumatsub, K.,  Inouea, M.,  Iwataa, S.,  Yoshidaa, R.,   Shigemuraa, N., Yanagawac, Y., Drucker, D. J., Margolskee, R. F., Ninomiyaa, Y. Glucagon like peptide-1 underlies sweet taste transmission FASEB J 2015 Jun;29(6):2268-80

Koehler, J. A., Baggio, L. L., Cao, X., Abdulla, T., Campbell, J. E., Secher, T., Jelsing, J., Larsen, B., Drucker, D. J. Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis Diabetes 2015; 64:1046-1056

Drucker, D. J. Deciphering metabolic messages from the gut drives therapeutic innovation: the 2014 banting lecture Diabetes. 2015 Feb;64(2):317-26

Ali, S., Ussher, J. R., Baggio, L. L., Kabir, M. G., Charron, M. J., Ilkayeva, O., Newgard, C. B., Drucker, D. J. Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction Molecular Metabolism 4 (2015), pp. 132-143

Finan, B.,  Yang, B.,Ottaway, N., Smiley, D. L.,  Ma, T., Clemmensen, C.,   Chabenne, J.,  Zhang, L., Habegger, K. M., Fischer, K., Campbell, J. E.,  Sandoval, D., Seeley, R. J.,  Bleicher, K.,  Uhles, S., Riboulet, W.,  Funk, F.,  Hertel, C., Belli, S.,Sebokova, S., Conde-Knape, K.,  Konkar, A., Drucker, D. J., Gelfanov, V., Pfluger, P. T., Müller, T. D.,  Perez-Tilve, D., DiMarchi, R. D., Tschöp, M. H A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents Nature Medicine 2015 Jan;21(1):27-36

Lovshin, J. A., Barnie, A., DeAlmeida, A., Logan, A., Zinman, B., Drucker, D. J. Liraglutide promotes natriuresis but does not increase circulating levels of atrial natriuretic peptide in hypertensive subjects with type 2 diabetes Diabetes Care 2015 Jan;38(1):132-9



Gagnon, J., Baggio, L. L., Drucker, D. J., Brubaker, P. L. Ghrelin is a novel regulator of glucagon-like peptide-1 secretion Diabetes  2014, doi: 10.2337/db14-1176

Koehler, J. A., Baggio, L. L., Cao, X., Abdulla, T., Campbell, J. E., Secher, T., Jelsing, J., Larsen, B., Drucker, D. J. Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis Diabetes 2015; 64:1046-1056

Mulvihill, E., and Drucker D. J. Pharmacology, Physiology and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors Endocrine Reveiws 2014 35:6;992-1019

Baggio, L. L., Drucker, D. J., Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight J Clin Invest. 2014 Sep 9:1-4

Moffett, R. C., Vsu, S., Thorens, B., Drucker, D. J., Flatt, P. R. Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy PLOS One 2014 9(6) DOI: 10.1371/journal.pone.0096863

Ussher, J. R.,, Baggio, L. L., Campbell, J. E., Mulvihill, E. E., Kim, M.,  Kabir, M. G., Cao, X.,  Baranek, J., Stoffers, D. A., Seeley, R. J., Drucker, D. J. Inactivation of the cardiomyocyte Glucagon-Like Peptide-1 Receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection  Molecular Metabolism Volume 3, Issue 5, August 2014, Pages 507–517

Ussher, J. R. and Drucker, D. J. Cardiovascular Actions of Incretin-Based Therapies 2014 May 23;114(11):1788-1803

Johswich A, Longuet C, Pawling J, Abdel Rahman A, Ryczko M, Drucker D. J., Dennis J. W. N-glycan Remodeling on Glucagon Receptor is an Effector of Nutrient-sensing by the Hexosamine Biosynthesis Pathway J. Biol Chem 2014 Jun 6;289(23):15927-1594

Ye, J., Hao, Z., Mumphrey, M. B., Townsend, R. L., Patterson, L. M., Stylopoulos, N., Münzberg, H. Morrison, C. D., Drucker, D. J., Berthoud, H.-R. GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents Am J Physiol 2014 Mar;306(5):R352-62


Mokadem, M., Zechner, J. F., Margolskee, R. F., Drucker, D. J., Aguirre, V. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency Molecular Metabolism, 2013 Dec 11;3(2):191-201. doi: 10.1016/j.molmet.2013.11.010

Wichmann, A., Allahyar, A., Greiner, T. U., Plovier, H., Östergren Lundén, G., Larsson, T., Drucker, D. J., Delzenne, N. M., Cani, P. D., Bäckhed, F. Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit Cell Host and Microbe 2013 14(5)582-590

Nguyen, A., Thoai., Mandard, S.,  Dray, C., Deckert, V., Besnard, P., Drucker, D. J., Lagrost, L., Grober, J. Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: Involvement of the glucagon-like peptide 1 (GLP1) pathway. Diabetes 2014 Feb;63(2):471-82

Finan, B., Ma, T., Ottaway, N.,Timo, Müller, D., Habegger, K.M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C. Lockie, S. H. Smiley, D. L., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J., Vignati, L., Zhang, L., Hauptman, J. B. Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E. Conde-Knape, K., Konkar, A., DiMarchi, R. D., Tschöp M. H., Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans  Sci Translational Med 30 October 2013 Vol 5 Issue 209 209ra151


Drucker, D. J., and Yusta, B. Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-Like Peptide-2 Annu Rev Physiol. 2014:76;561-583

Fujita, H.,  Morii, T., Fujishima, H., Sato, T., Shimizu, T., Hosoba, M., Tsukiyama, K., Narita, T., Takahashi, T., Drucker, D. J., Seino, Y., Yamada, Y. The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential Kidney International 2014 Mar;85(3):579-89

Mukharji, A., Drucker, D. J., Charron, M. J., and Swoap, S. J. Oxyntomodulin increases intrinsic heart rate through the glucagon receptor Physiological Reports  20 OCT 2013, DOI: 10.1002/phy2.112

Drucker, D. J. Incretin action in the pancreas: Potential promise, possible perils, and pathological pitfalls Diabetes 2013 62 3316-3323

Campbell, J.E., Drucker, D. J. Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action 2013 Jun 4;17(6):819-37

Kim, M., Platt, M., Shibasaki, T., Quaggin, S., Backx, P. H., Seino, S., Simpson, J.,  Drucker, D. J. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure Nature Medicine 2013 May;19(5):567-7

Sadry, S., Drucker D. J., Emerging combinatorial hormone therapies for the treatment of obesity and T2DM Nat Rev Endo 2013 Mar 12;9(7):425-33. doi: 10.1038/nrendo.2013.47

Noyan-Ashraf M.H., Shikatani E.A., Schuiki I., Mukovozov I.M., Wu J., Li R.K., Volchuk A., Robinson L.A., Billia F., Drucker D.J., Husain M. A glucagon-like peptide-1 analogue reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity Circulation 2013;127:74-85

Burmeister MA, Ayala JE, Drucker DJ, Ayala JE Central Glucagon-Like Peptide 1 Receptor (Glp1r)-Induced Anorexia Requires Glucose Metabolism-Mediated Suppression of AMPK and is Impaired by Central Fructose Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E677-85

Panjwani, N., Mulvihill, E., Longuet, C., Yusta, B., Campbell, J. E., Brown, T. J., Streutker, C., Holland, D., Cao. X., Baggio, L. L., and Drucker, D. J. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE-/- mice Endocrinology 2013 154: 127-139

Longuet, C., Robledo, A.M., Dean, E.D., Dai, C., Ali, S., McGuinness, I., de Chavez, V., Vuguin, P.M., Charron, M.J., Powers, A.C., and Drucker, D.J. Liver-specific disruption of the murine glucagon receptor produces alpha-cell hyperplasia: evidence for a circulating alpha-cell growth factor Diabetes April 2013 62:1196-1205

Fukami, A., Seino, Y., Ozaki, N., Yamamoto, M., Sugiyama, C., Sakamoto-Miura, E.,  Himeno, T., Takagishi, Y., Tsunekawa, S., Ali, S., Drucker, D.J., Murata, Y., Seino, Y.,  Oiso, Y., and Hayashi, Y. Ectopic expression of GIP in pancreatic b-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides Diabetes 2013 62:510-518

Flock, G. B., Cao, X., Maziarz, M., and Drucker D. J. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice Diabetes 2013 62:283-290


Lockie, S. H., Heppner, K. M.,  Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschöp, M. H., Perez-Tilve, D. Direct control of Brown Adipose Tissue thermogenesis by Central Nervous System Glucagon-Like Peptide-1 receptor signaling Diabetes 2012 ;61(11):2753-62

Martin, C., Passilly-Degrace, P., Chevrot, M., Ancel, D., Sparks, S. M., Drucker, D. J., and Besnard, P. Lipid- mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity J Lipid Res 2012 in press

Burmeister M.A., Bracy D.P., James F.Y., Holt R.M., Ayala J., King E.M., Wasserman D.H., Drucker D.J. and Ayala J.E. Regulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor J Physiol. 2012 Aug 13. in press

Rieg, T., Gerasimova, M., Murray, F., Masuda, T., Tang, T., Rose, M.,  Drucker, D.J., and Vallon, V. The natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice Am J Physiol Renal Physiol. 2012 Jul 25.

Yusta, B., Holland, D., Waschek, J., Drucker, D. J. Intestinotrophic Glucagon-Like Peptide-2 (GLP-2) Activates Intestinal Gene Expression and Growth Factor-Dependent Pathways Independent of the Vasoactive Intestinal Peptide Gene in Mice Endocrinology Jun;153(6):2623-32

Ussher, J. R., and Drucker, D. J. Cardiovascular biology of the incretin system Endocrine Reviews 2012 doi:10.1210/er.2011-1052

Lee, S-J., Lee, J., Li, K. K., Holland, D., Maughan, H., Guttman, D. S., Yusta, B., and Drucker D. J. Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis Endocrinology 2012 Mar;153(3):1141-51

Lamont, B., Li, Y., Kwan, E.,  Brown, T. J., Gaisano, H., and Drucker D. J. Pancreatic GLP-1 receptor activation is sufficient for GLP-1R-dependent control of glucose homeostasis in mice J Clin Invest 2012 Jan 3;122(1):388-402

Bates, H., Campbell, J. E., Ussher, J. R., Baggio, L. L., Maida, A., Seino, Y., and Drucker D. J. The Gipr is essential for adrenocortical steroidogenesis however corticosterone deficiency does not mediate the favourable metabolic phenotype of Gipr-/- mice Diabetes 2012 61:40-48


Ellingsgaard, H., Hauselmann, I.,  Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T.,  Eppler, E.,  Bouzakri, K.,  Wueest, S., Muller, Y. D., Hansen, A. M., Reinecke, M., Konrad, D., Gassmann, M., Reimann, F., Halban, P. A., Gromada, J., Drucker, D. J., Gribble, F. M., Ehses, J. A., and Donath, M. Y.  Interleukin-6 enhances insulin secretion by increasing L cell and a cell glucagon-like peptide-1 secretion Nature Medicine 2011 Oct 30;17(11):1481-9.

Barthson, J., Germano, C.M., Moore, F., Maida, A., Drucker, D.J. Marchetti, P., Gysemans, C., Mathieu, C., Nuñez, G.,  Jurisicova, A., Eizirik, D.L., Gurzov, E.N., Tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated bim activation J. Biol. Chem. 2011 jbc.M111.253591. First Published on September 21, 2011, doi:10.1074/jbc.M111.253591

Drucker, D. J., and Rosen, C. F. GLP-1 receptor agonists, obesity and psoriasis: diabetes meets dermatology Diabetologia 2011 54:2741-2744

Drucker, D. J. Incretin-based therapy and the quest for sustained improvements in beta cell health Diabetes Care 2011 34(9): 2133-35

Cabou, C., Vachoux, C., Campistron, G., Drucker,  D. J. and Burcelin, R. Brain GLP-1 signaling regulates controls femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ Diabetes 2011 Sep;60(9):2245-2256

Himeno, T., Kamiya, H., Naruse, K., Harada, N., Ozaki, N., Seino, Y., Shibata, T., Kondo, M., Kato, J., Okawa, T., Fukami, A., Hamada, Y., Inagaki, N., Seino, Y., Drucker, D. J., Oiso, Y., and  Nakamura, J. Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice Diabetes 2011 Sep;60(9):2397-2406

Chen, M., Mema, E., Kelleher, Nemechek, J. N., Berger, A., Wang, J., Xie, T., Gavrilova, O., Drucker, D. J., Weinstein, L. S. Absence of the Glucagon-Like Peptide-1 Receptor Does Not Affect the Metabolic Phenotype of Mice with Liver-Specific Gsa Deficiency Endocrinology 2011 Sep;152(9):3343-50

Koehler, J. A., Kain, T., Drucker, D. J. Glucagon-like peptide-1 receptor activation inhibits growth and augments apoptosis in murine CT26 colon cancer cells Endocrinology 2011, Sep;152(9):3362-72

Drucker, D. J., Sherman, S. I., Bergenstal, R. M., and Buse, J. B. The safety of incretin-based therapies; review of the scientific evidence J Clin Endocrinol Metab 2011 96(7);2027-2031

Dao T. M., Waget A., Klopp P., Serino M., Vachoux C., Pechere L., Drucker D. J., Champion S., Barthélemy S., Barra Y., Burcelin R., Sérée E. Resveratrol Increases Glucose Induced GLP-1 Secretion in Mice: A Mechanism which Contributes to the Glycemic Control PLoS One. 2011;6(6):e20700

Waget, A., Cabou, C., Masseboeuf, M., Cattan, P., Armanet, M., Karaca, M., Castel, J., Garret, C., Payros, G., Maida, A., Sulpice, T., Holst, J.J., Drucker, D. J., Magnan, C., Burcelin, R. Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice Endocrinology 2011 Aug;152(8):3018-29

Ali, S., Lamont, B.J., Charron, M., and Drucker D. J. Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis J Clinical Investigation J Clin Invest 2011;121(5):1917–1929. doi:10.1172/JCI43615

Drucker, D. J. & Goldfine, A. B. Cardiovascular safety and diabetes drug development Lancet 2011 Mar 19;377(9770):977-9

Kyle, K.A., Willett, T.L., Baggio, L.L., Drucker, D. J., Grynpas, M. Differential Effects of PPAR-g Activation vs. Chemical or Genetic reduction of DPP-4 Activity on Bone Quality in Mice Endocrinology 2011 Feb 152(2):457-67


Flock, G., Cao, X., Seino, Y., and Drucker D. J. GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms Endocrinology 2011 Feb;152(2):374-83

Maida, A., Lamont, B. J., Cao, X., and Drucker, D. J. Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice Diabetologia 2011 54;339-349


Ayala, J. E., Bracy, D. P., James, F. D., Burmeister, M. A., Wasserman, D. H.and Drucker, D. JGlucagon-like Peptide-1 Receptor Knockout Mice are Protected from High Fat Diet-Induced Insulin Resistance Independent of Effects on Body Composition Endocrinology 2010 Oct;151(10):4678-87

Bahrami, J., Longuet, C., Baggio, L.L., Li, K., and Drucker, D. J.  The glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse Gastroenterology 2010 Sep;139(3):857-868

Drucker, D. J., Dritselis, A., Fitzpatrick, P. Liraglutide Nature Reviews Drug Discovery 2010 9:267-268

Bahrami, J., Yusta, B., and Drucker, D. J. ErbB activity links the glucagon-like peptide-2 receptor to refeeding-induced adaptation in the murine small bowel Gastroenterology 2010 Jun;138(7):2447-56.

Buse, J. B., Drucker, D. J., Taylor, K. L., Kim, T., Walsh, B., Hu, H., Wilhelm, K., Trautmann, M., Shen, L. Z., Porter, L. E., and the DURATION 1 Study Group DURATION-1: Exenatide Once Weekly Produces Sustained Glycemic Control and Weight Loss Over 52 Weeks Diabetes Care 2010 Jun;33(6):1255-61

Knudsen, L. B., Madsen, L.W., Andersen, S., Almholt, K., de Boer, A. S., Drucker, D. J., Gotfredsen, C., Egerod, F. L., Hegelund, A. C., Jacobsen, H., Jacobsen, S. D.,  Moses, A. C., Molck, A. M., Nielsen, H. S., Nowak, J., Solberg, H., Thi, T. D. L., Zdravkovic, M. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation Endocrinology 2010 151: 1473-1486

Ban, K., Kim, K.-H., Cho, C.-K., Sauvé, S., Diamandis, E. P., Backx, P. H., Drucker, D. J., and Husain, M. GLP-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor Endocrinology 2010 151: 1520-1531

Drucker, D. J., Sherman, S. I., Gorelick, F. S., Bergenstal, R. M., Sherwin, R. S., and Buse, J. B. Incretin-based therapies for the treatment of type 2 diabetes; evaluation of the risks and benefits Diabetes Care 2010 33:428-433

Sauve, M., Ban, K., Momen, M. A.,  Zhou, Y-Q., Henkelman, R. M., Husain, M., and Drucker, D. J. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes following myocardial infarction in mice Diabetes 2010 Apr;59(4):1063-73

Hadjiyanni, I., Siminovitch, K. A., Danska, J. S., Drucker D. J. Glucagon-like peptide-1 receptor (GLP-1R) signaling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T-cells Diabetologia 2010 Apr;53(4):730-40

Hsieh, J., Longuet, C., Baker, C. L., Qin, B., Federico, L. M., Drucker, D. J., Adeli, K. The glucagon-like peptide-1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice Diabetologia 2010 Mar;53(3):552-61.


Barrera, J. G., D'Alessio, D. A., Drucker, D. J., Woods, S. C., and Seeley, R. J. Differences in the central anorectic effects of GLP-1 and exendin-4 in rats Diabetes 2009 Dec;58(12):2820-7

Maida, A., Hansotia, T., Longuet, C., Seino, Y., Drucker, D. J. Differential importance of GIP vs. GLP-1 receptor signaling for beta cell survival in mice Gastroenterology 2009 137 (6), December 2009, 2146-2157

Belsham, D. D., Fick, L. J., Dalvia, P. S., Centeno, M.-L., Chalmers, J. A., Lee, P. K. P., Yang, Y., Drucker, D. J., and Koletar, M. M. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis allowing immortalization of adult murine hypothalamic neurons FASEB J. 2009 Dec; 23 (12):4256-65

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, Z., Mastronardi, F., Maezawa, Y., Drucker, D. J., Engleman, E., Winer, D., and Dosch, H.-M. Normalization of obesity-associated insulin-resistance through immunotherapy Nature Medicine 2009  (15) 921-929

Day, J., Ottaway, N., Patterson, J., Gelfanov, V., Smiley,  D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D.J., Chaudhary, N., Holland, J., Hembree, J., Abplanalp, W., Grant, E., Ruehl, J., Wilson, H., Kirchner, H., Lockie, S., Hofmann, S., Woods, S., Nogueiras, R., Pfluger, P., Perez-Tilve, D., DiMarchi, R., and Tschop, M. A novel glucagon/GLP-1 co-agonist eliminates obesity in rodents Nature Chemical Biology 2009 Oct;5(10):749-57

Yusta, B., Holland, D., Koehler, J.A., Maziarz, M., Estall, J. L., Higgins, R., Drucker, D. J. ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut Gastroenterology Sep;137(3):986-96.

Koehler, J. K., Baggio, L. L., Lamont, B. J., Ali, S., and Drucker D. J. GLP-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice  Diabetes 2009 58:2148-2161

Ban, K., Hui, S., Drucker, D. J., and Husain, M. Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin-based therapies 2009 Journal of the American Society of Hypertension  DOI: 10.1016/ July 2009 Vol. 3 (4) 245-259

Hsieh J, Longuet C, Maida A, Bahrami J, Xu E, Baker CL, Brubaker PL, Drucker DJ, Adeli K. Glucagon-like Peptide-2 Increases Intestinal Lipid Absorption and Chylomicron Production via CD36 Gastroenterology. 2009 Sep;137(3):997-1005

Lovshin, J. A. and Drucker D. J. Incretin-based therapies for type 2 diabetes mellitus Nature Reviews Endocrinology 2009 5(5) 262-269

Noyan-Ashraf M. H., Momen M. A., Ban K., Sadi A. M., Zhou Y. Q., Riazi, A. M., Baggio L. L., Henkelman R.M., Husain M., Drucker D. J. The GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes following experimental myocardial infarction in mice. Diabetes 2009 Apr;58(4):975-83.

Ali, S., and Drucker D. J. Am J Physiol Endo Metab Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes Am J Physiol Endocrinol Metab Mar 2009; 296:E415-E421

Ayala, J., Bracy, D. P., James, F. D., Julien, B. M., Wasserman, D. H., and Drucker, D. J. The Glucagon-like Peptide-1 Receptor Regulates Endogenous Glucose Production and Muscle Glucose Uptake Independent of its Incretin Action Endocrinology 2009 Mar;150(3):1155-64

Hadjiyanni, I, Li, K., and Drucker D. J. Glucagon like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the non obese diabetic mouse Endocrinology 2009 Feb;150(2):592-9

Martin, B., Dotson, C. D., Shin, Y. K., Ji, S., Drucker, D. J., Maudsley, S., and Munger, S. D. Modulation of taste sensitivity by GLP-1 signaling in taste buds Annals of the New York Academy of Sciences 2009 1170:98-101

Duez, H., Smith, A.C., Xiao, C., Giacca, A., Szeto, L., Drucker, D.J., and Lewis, G. F. Acute DPP-4 Inhibition rapidly Enhances Insulin-mediated Suppression of Endogenous Glucose Production in Mice Endocrinology 2009 Jan;150(1):56-62



Longuet, C., Sinclair, E.M., Maida, A., Baggio, L.L., Maziarz, M., Charron, M.J., and Drucker, D.J. Glucagon is essential for control of hepatic lipid metabolism and the adaptive metabolic response to fasting Cell Metabolism 2008:8; 359-371

Koehler, J. A., Harper, W., Barnard, M., Yusta, B., and Drucker D. J. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells Can Res 2008 68:7897-7904

Drucker, D. J., Buse, J.B., Taylor, K., Kendall, D., Trautmann, M., Zhuang, D., Porter, L. 2008 Exenatide Once Weekly versus Twice Daily for the Treatment of Type 2 Diabetes Lancet 2008 372:1240-50

Patel, S., Doble, B. W., MacAulay, K., Sinclair, E. M. Drucker, D. J. and. Woodgett, J. R. Tissue-specific role of glycogen synthase kinase-3 in glucose homeostasis and insulin action Mol. Cell. Biol. 2008:28;6314-6328

Sinclair, E.M., Yusta, B., Streutker, C., Baggio, L.L., Koehler, J., Charron, M.J., and Drucker D. J. Glucagon receptor signaling is essential for control of murine hepatocyte survival Gastroenterology 2008 Dec;135(6):2096-106

Maida, A., Lovshin, J. L., Baggio, L.L. and Drucker D. J. The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice Endocrinology 2008 149;5670-5678

Cabou, C., Campistron, Marsollier, G. N., Corinne Leloup, C., Cruciani-Guglielmacci, C., Pénicaud, L., Drucker, D. J., Magnan, C., and Burcelin, R. Brain GLP-1 regulates arterial blood flow, heart rate and insulin sensitivity Diabetes Oct;57(10):2577-87.

Knauf, C., Cani, P. D., Kim, D.-H., Iglesias, M. A., Chabo, C., Waget, A., Colom, A., Rastrelli, S., Delzenne, N.M., Drucker, D. J., Seeley, R. J., and Burcelin, R. The role of CNS GLP-1 receptors in enteric glucose sensing Diabetes 2008 57:2603-2612

Retnakaran, R., and Drucker, D.J. Intensive insulin therapy in newly diagnosed type 2 diabetes Lancet 2008 371:1725-1726

Picha, K. M., Cunningham, M. R., Drucker, D. J., Mathur, A., Ort, T., Scully, M., Soderman, A., Spinka-Doms, T., Stojanovic-susulic, V., Thomas, B. A., and O’Neil, T. Protein engineering strategies for sustained GLP-1R-dependent control of glucose homeostasis Diabetes 2008 Jul;106(1):455-63

Ban, K., Noyan-Ashraf, M. H., Hoefer, J., Bolz, S.-S., Drucker, D. J., and Husain, M. Cardioprotective and vasodilatory actions of GLP-1 are mediated through both GLP-1 receptor-dependent and independent pathways Circulation 2008 May 6;117(18):2340-50.

Shin, Y. K., Martin, B., Golden, E., Dostson, C. D., Maudsely, S., Kim, W., Jang, H. J., Mattson, M. P., Drucker, D. J., Egan, J. M., and Munger, S. D. Modulation of taste sensitivity by GLP-1 signaling J. Neurochem 2008 Jul;106(1):455-63

Ayala, J. E., Bracy, D. P., Hansotia, T., Flock, G., Seino, Y., Wasserman, D. H., and Drucker, D. J. Insulin action in the double incretin receptor knockout mouse Diabetes 2008 57: 288 -297

Hadjiyanni, I., Baggio, L. L., Poussier, P., and Drucker, D.J. Endocrinology 2008 Mar;149(3):1338-49

Kumar, K. G., Byerley, L., Volaufova, J., Drucker, D. J., Churchill, G. A., Li, R., York, B., Zuberi, A., Smith Richards, B. K. Genetic variation in Glp1r expression influences the rate of gastric emptying in mice. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R362-71

Yamada, C., Yamada, Y., Tsukiyama, K., Yamada, K., Udagawa, N., Takahashi, N., Tanaka, K., Drucker, D. J., Seino, Y., and Inagaki, N. The murine Glp1r is essential for control of bone resorption Endocrinology 2008 149: 574-579

Goldberg, R. B., Holman, R., and Drucker D. J. Management of type 2 diabetes New Eng J Med 2008 358:293-297

Baggio, L. L., Cao, X., Huang, Q., and Drucker, D. J.. An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis Gastroenterology 2008, Apr; 134(4): 1137-47

Lamont, B., and Drucker, D. J. Differential anti-diabetic efficacy of incretin agonists vs. DPP-4 inhibition in high fat fed mice Diabetes 2008 57: 190 -198


Hadjiyanni, I., and Drucker, D. J. Glucagon-Like Peptide 1 and Type 1 Diabetes: NOD Ready for Prime Time? Endocrinology. 2007 Nov;148(11):5133-5

Wideman, R. D., Covey, S. D., Webb, G. C., Drucker, D. J., Kieffer, T. A Switch from PC2 to PC1/3 Expression in Transplanted {alpha}-cells is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice. Diabetes. 2007 56:2744-2752, 2007

Macaulay, K., Doble, B. W., Patel, S., Hansotia, T., Sinclair, E. M., Drucker, D. J., Nagy, A., and Woodgett, J. R. Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism Cell Metab 2007 (6) 329-337

Flock, G., Baggio, L. L., Longuet, C., and Drucker, D. J. The incretin receptors for GLP-1 and GIP are essential for the sustained metabolic actions of vildagliptin in mice Diabetes 2007 :56:3006-3013

Cani, P. D., Holst, J.J., Drucker, D. J., Delzenne, N. M., Thorens, B., Burcelin, R., and Knauf, C. GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol. 2007 Sep 30;276(1-2):18-23

Drucker D. J. Dipeptidyl Peptidase-4 Inhibition and the Treatment of Type 2 Diabetes: Preclinical biology and mechanisms of action Diabetes Care 2007 30: 1335-1343

Baggio, L. L. and Drucker, D. J. Biology of Incretins: GLP-1 and GIP Gastroenterology, Volume 132, Issue 6, May 2007, Pages 2131-2157

Drucker, D. J. Unraveling the complexities of gut endocrinology Nature Clinical Practice Endocrinology & Metabolism April 2007 3(4)317

Drucker D. J. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: Preclinical biology and mechanisms of action Diabetes Care 2007 in press

Drucker, D. J., Easley, C., and Kirkpatrick, P. Sitagliptin Nature Reviews Drug Discovery 2007 (6) 2; 109-110

Drucker D. J. The role of gut hormones in glucose homeostasis. J. Clin. Invest. 2007 117: 24-32

Sowden, G. L., Drucker, D. J., Weinshenker, D.,  Swoap, S. J.Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor. Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R962-70. Epub 2006 Oct 12

Hansotia, T., Maida, A., Flock, G., Yamada, Y., Tsukiyama, K., Seino, S., and Drucker, D. J. Extrapancreatic incretin receptors modulate glucose homeostasis and energy expenditure J Clin Invest 2007 January 2; 117(1): 143–15


Drucker, D. J. and Nauck, M. A. The incretin system: glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes Lancet 2006 368: 1696-705

Yusta, B., Baggio, L. L., Estall, J. E., Koehler, J. A., Holland, D. P., Li, H., Pipeleers, D., Ling, Z., and Drucker, D. J. GLP-1 receptor activation improves b-cell function and survival following induction of endoplasmic reticulum stress Cell Metabolism 2006 Nov;4(5):391-406

Drucker, D. J. Enhancing the Action of Incretin Hormones: A New Whey Forward? Endocrinology Vol. 147, No. 7 3171-3172

Estall, J. L., and Drucker, D. J. Glucagon and glucagon-like Peptide receptors as drug targets. Curr Pharm Des. 2006;12(14):1731-50

Baggio, L. L., Holland, D., Wither, J., and Drucker D. J. Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-Exendin) transgenic mice Diabetes 2006 Jun;55 (6): 1562-70.

Cani, P. D.,  Knauf, C.,  Iglesias, M. A., Drucker, D. J.,  Delzenne, N. M., and  Burcelin, R. Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor Diabetes 2006 55: 1484-1490

Estall, J. L.&  Drucker, D. J. Glucagon-Like Peptide-2.Annu Rev Nutr. 2006 2006;26:391-411

Koehler, J. A, and Drucker, D. J.  Activation of GLP-1 receptor signaling does not modify the growth or apoptosis of human pancreatic cancer cells Diabetes 2006 55: 1369-1379

Drucker, D. J. The biology of incretin hormones. Cell Metab. 2006 Mar;3(3):153-65. Review

Riddle, M. C., Drucker D. J.  Emerging therapies mimicking the effects of amylin and glucagon-like Peptide 1. Diabetes Care. 2006 Feb;29(2):435-49

Baggio, L. L. and Drucker, D. J. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annu Rev Med. 2006; 57:265-81

Drucker, D. J. The evidence for achieving glycemic control with incretin mimetics. Diabetes Educ. 2006 Mar-Apr;32(2 Suppl):72S-81S.

Drucker, D. J.  Incretin-based therapies: a clinical need filled by unique metabolic effects. Diabetes Educ. 2006 Mar-Apr;32(2 Suppl):65S-71

Drucker D. J. Gastrointestinal Peptide Hormones Regulating Energy and Glucose Homeostasis Chapter 6 Physiology of the GI Tract, 4th Edition Academic Press 2006


Knauf, C.,  Cani, P. D.,  Perrin, C., Iglesias, M. A., Maury, J.-F.,  Bernard, E.,  Benhamed, F.,  Gremeaux, T.,  Drucker, D. J., Kahn, C. R., Girard, J., Tanti, J.-F.,  Delzenne, N. M.,  Postic, C., and Burcelin, R. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage J. Clin. Invest. 2005;115 3554-3563

Drucker, D. J. Biological actions and therapeutic potential of the proglucagon-derived peptides Nature Clinical Practice Endocrinology & Metabolism (2005) 1, 22-31

Sinclair, E. M. and Drucker, D. J. Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential Physiology, Oct 2005; 20: 357 - 365

Talsania T., Anini Y., Siu S, Drucker D. J., Brubaker P.L. Peripheral Exendin-4 and Peptide YY3-36 Synergistically Reduce Food Intake through Different Mechanisms in Mice. Endocrinology. 2005 Sep;146(9):3748-56. Epub 2005 Jun 2.

Shin, E. D., Estall, J. L., Izzo, A., Drucker, D. J., and Brubaker, P. L. Mucosal Adaptation to Enteral Nutrients is Dependent on the Physiologic Actions of Glucagon-Like Peptide-2 in Mice. Gastroenterology. 2005 May;128(5):1340-53.

Schonhoff, S.,  Baggio, L.,  Ratineau, C., . Ray, S. K.,  Lindner, J., Magnuson, M.A., . Drucker, D. J., and Leiter, A. B. Energy Homeostasis and Gastrointestinal Endocrine Differentiation Do Not Require the Anorectic Hormone Peptide YY Mol. Cell. Biol. 2005 25: 4189-4199. 

Estall, J. L.,   Koehler, J. A.,  Yusta, B., and  Drucker, D. J. The GLP-2R C-terminus modulates beta-arrestin-2 association, but is dispensable for ligand-induced desensitization, endocytosis and G-protein-dependent effector activation J. Biol. Chem., Apr 2005 Jun 10;280(23):22124-34. Epub 2005 Apr 6

Hansotia, T., Drucker, D. J. GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice. Regul Pept. 2005 Jun 15;128(2):125-34

Maziarz M., Chung C., Drucker D.J., Emili A Integrating global proteomic and genomic expression profiles generated from islet α cells: Opportunities and challenges to deriving reliable biological inferences. Mol Cell Proteomics. 2005  Apr;4(4):458-474

Sinclair, E. M., and Drucker, D. J. Glucagon-like peptide-1 receptor agonist and DPP-IV inhibitors: new therapeutic agents for the treatment of type 2 diabetes. Current Opinion in Endocrinology and Metabolism 2005 12:146-151

Li, Y.,  Cao, X., Li, L.-X., Brubaker, P.L., Edlund, H., and  Drucker, D.J. ß-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1. Diabetes 2005 54: 482-491

Reimann F., Maziarz M., Flock G., Habib A.M., Drucker D.J., Gribble F.M. Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line. J Physiol. 2005 Feb 15;563(Pt 1):161-75

Koehler, J., Yusta, B., and Drucker, D. J. The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways Mol Endocrinol. 2005 Feb;19(2):459-73

Estall, J. L. Drucker, D. J. Tales beyond the Crypt: Glucagon-Like Peptide-2 and Cytoprotection in the Intestinal Mucosa. Endocrinology. 2005 Jan; 146(1): 19-21

Flock, G., Cao, X., and Drucker, D. J. Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells Endocrinology 2005 146: 441-449

Lachey, J. L., D'Alessio, D. A., Rinaman, L., Elmquist, J. K., Drucker, D. J., Seeley, R. J. The role of central GLP-1 in mediating the effects of visceral illness: Differential effects in rats and mice Endocrinology 2005 146: 458-462


Baggio L.L., Kim J.G., Drucker D.J. Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R-Dependent Glucose Homeostasis In Vivo. Diabetes. 2004 Dec;53 Suppl 3:S205-14

Baggio, L. L., and Drucker, D. J. Glucagon-like peptide-1 and glucagon-like peptide-2. Best Pract Res Clin Endocrinol Metab. 2004 Dec;18(4):531-54.

Baggio, L.L., Huang Q, Brown T. J, Drucker DJ. A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis Diabetes 2004 53: 2492-2500

Baggio L. L., Huang Q, Brown T. J, Drucker DJ. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology. 2004 Aug;127(2):546-58

Estall, J. L., Yusta, B., and Drucker, D. J. Lipid Raft-dependent GLP-2 Receptor Trafficking Occurs Independently of Agonist-induced Desensitization.  Mol Biol Cell. 2004 Aug;15(8):3673-87

Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A.,  Yamada, Y., Tsukiyama, K., Seino, Y., Holst, J. J., Schuit, F., and Drucker, D. J. Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors Diabetes 2004 53: 1326-1335

Preitner, F., Ibberson, M., Franklin, I., Binnert, C., Pende, M., Gjinovci, A., Hansotia, T., Drucker, D. J., Wollheim, C., Burcelin, R., Thorens, B. Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors J Clin Invest 2004 113:635-645

Lovshin J.A., Huang Q., Seaberg R., Brubaker P.L., Drucker D.J. Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells. Endocrinology. 2004 Jul;145(7):3495-506.

Brubaker, P. L., Drucker DJ Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology. 2004 Jun;145(6):2653-9


Drucker, D. J. Glucagon-Like Peptide-1 and the Islet ß-Cell: Augmentation of Cell Proliferation and Inhibition of Apoptosis Endocrinology 2003 144: 5145-5148

Estall, J. L., Drucker, D. J. Dual Regulation of Cell Proliferation and Survival via Activation of Glucagon-Like Peptide-2 Receptor Signaling. J Nutr. 2003 Nov;133(11):3708-11

Boushey, R. P.,  Abadir, A., Flamez, D., Baggio, L. L., Li, Y., Berger, V., Marshall, B. A.,  Finegood, D., Wang, T. C.,  Schuit, F., and Drucker, D. J. Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene Gastroenterology 2003 125:1164-174

Drucker, D. J.Enhancing Incretin Action for the Treatment of Type 2 Diabetes Diabetes Care 2003 26: 2929-2940

Walsh NA, Yusta B, DaCambra MP, Anini Y, Drucker DJ, Brubaker PL Glucagon-like Peptide-2 receptor activation in the rat intestinal mucosa. Endocrinology. 2003 Oct;144(10):4385-92. Epub 2003 Jul 03

During M.J., Cao L, Zuzga D.S., Francis J.S., Fitzsimons H.L., Jiao X., Bland R.J., Klugmann M., Banks W.A., Drucker DJ, Haile CN Glucagon-like peptide-1 receptor is involved in learning and neuroprotection.  Nat Med. 2003 Sep;9(9):1173-1179. Epub 2003 Aug 17

Gros, R., You, X., Baggio, L. L., Kabir, M. G., Sadi, A-M., Mungrue, I. N.,. Parker, T. G., Huang, Q., Drucker, D. J., and Husain, M. Cardiac function in mice lacking the GLP-1 rece p tor Endo crinology 2003 144(6) 2242-2252

Cao X, Flock G, Choi C, Irwin DM, Drucker DJ. Aberrant Regulation of Human Intestinal Proglucagon Gene Expression in the NCI-H716 Cell Line. Endocrinology. 2003 May;144(5):2025-33

Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK. Glucagon-Like Peptide-1-Responsive Catecholamine Neurons in the Area Postrema Link Peripheral Glucagon-Like Peptide-1 with Central Autonomic Control Sites. J Neurosci. 2003 Apr 1;23(7):2939-2946

Mayo, K. E., Miller, L. J.,  Bataille, D., Dalle, S., Göke, B., Thorens, B., and Drucker, D. J. International Union of Pharmacology. XXXV. The Glucagon Rece p tor Family Pharmacol Rev 2003 55:167-194.

Kim, J.-G., Baggio, L.L., Bridon, D.P., Castaigne, J.-P., Robitaille, M.F., Jette, L., Benquet, C., and Drucker, D. J. Development and characterization of a GLP-1-albumin conjugate which retains the ability to activate the GLP-1 receptor in vivo. Diabetes 2003 52(3):751-9

Drucker, D. J. Glucagon-like peptides: Regulators of cell proliferation and apoptosis Mol Endocrinol 2003  17(2)161-171

DeLeon,  D. D., Deng, S., Madani, R., Ahima, R., Drucker, D.J., Stoffers, D. A. Role of Endogenous Glucagon-Like Peptide-1 (GLP-1) in Islet Regeneration after Partial Pancreatectomy Diabetes 2003 Feb;52(2):365-371.

Trinh, K.Y.T., Zhang, K., Hossain, M., Brubaker, P. L., and Drucker, D. J. Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium Diabetes 2003 Feb;52(2):425-33.

Drucker, D. J.Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes. Expert Opin Investig Drugs. 2003 Jan;12(1):87-100

Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker, D. J. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem.  2003 Jan 3;278(1):471-8

Lovshin, J. A., Drucker, D. J. Glucagon-like peptides, the central nervous system, and the regulation of energy homeostasis Curr Med chem CNS System Agents 2003, 3 73-80


Flock, G., and Drucker, D. J. Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine. Mol Endocrinol. 2002 Oct;16(10):2349-59.

Brubaker, P.L., and Drucker, D. J. Structure Function of the Glucagon Receptor Family of G Protein Coupled Receptors: The Glucagon, GIP, GLP-1, and GLP-2 Receptors. Receptors and Channels 2002 8:179-188

Adatia, FA, Baggio, LL, Xiao, Q, Drucker DJ, and Brubaker PL. Cellular specificity of proexendin-4 processing in Mammalian cells in vitro and in vivo. Endocrinology. 2002 Sep;143(9):3464-71

Brubaker PL, Drucker DJ, Asa SL, Swallow C, Redston M, Greenberg GR Prolonged Gastrointestinal Transit in a Patient with a Glucagon-Like Peptide (GLP)-1- and -2-Producing Neuroendocrine Tumor. J Clin Endocrinol Metab. 2002 Jul;87(7):3078-83

Yamamoto, H.,  Lee, C. E.,  Marcus, J. N., Williams, T. D., Overton, J. M.,  Lopez, M. E.,  Hollenberg, A. N., Baggio, L.,  Saper, C. B.  Drucker, D. J., and  Elmquist, J. K. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons J. Clin. Invest. 2002;110 43-52

Liu Y, Shen W, Brubaker PL, Kaestner KH, Drucker DJFoxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. Biochem J. 2002 Sep 1;366(Pt 2):633-41

Yusta B, Estall J, Drucker DJ. GLP-2 receptor activation engages Bad and glycogen synthase kinase 3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase. J Biol Chem. 2002 Jul 12;277(28):24896-906

Drucker, D. J. Gut adaptation and the glucagon-like peptides. Gut. 2002 Mar;50(3):428-35

Drucker, D. J. Biological Actions and Therapeutic Potential of the Glucagon-like Peptides Gastroenterology 2002;122 531-544

Nian, M., Irwin, D.M. , Drucker, D. J., Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression. Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R173-R183


Burcelin, R., Da Cost, A., Drucker, D., and Thorens, B. Glucose Competence of the Hepatoportal Vein Sensor Requires the Presence of an Activated Glucagon-Like Peptide-1 Receptor. Diabetes. 2001 Aug;50(8):1720-8.

Drucker, D. J. Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes. Curr Pharm Des. 2001 Sep 11;7(14):1399-412.

Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice. Virchows Arch 2001 Apr;438(4):382-7

Lovshin J, Estall J, Yusta B, Brown TJ, Drucker D.J. Glucagon-like peptide-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling. J Biol. Chem. 2001 Vol. 276, Issue 24, 21489-21499, June 15, 2001

Lefebvre D.L., Bai Y., Shahmolky N., Sharma M., Poon R., Drucker D.J., Rosen C.F. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. Biochem J 2001 Apr 15;355(Pt 2):297-305

Drucker, D. J. Glucagon-like peptide 2. J Clin Endocrinol Metab. 2001 Apr;86(4):1759-64.

Boushey, R. P., Yusta, B., and Drucker, D.J. Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor. Cancer Res. 2001 Jan 15;61(2):687-93

Drucker, D.J.  The glucagon-like peptides  Endocrinology 2001 142:521-527, 


Lovshin J, Yusta B, Iliopoulos I, Migirdicyan A, Dableh L, Brubaker PL, Drucker DJ Ontogeny of the glucagon-like peptide-2 receptor axis in the developing rat intestine Endocrinology 2000;141(11):4194-201

Baggio, L., Kieffer, T.J., and Drucker, D.J. GLP-1 but not GIP regulates fasting glycemia and non-enteral glucose clearance in mice Endocrinology 2000 Oct;141(10):3703-9

Tavares W, Drucker DJ, Brubaker P Enzymatic- and renal-dependent catabolism of the intestinotropic hormone glucagon-like peptide-2 in rats Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E134-9

Yusta, B., Huang, L., Munroe, D., Wolff, G., Fantaske, G., Demchyshyn, L., Asa, S.L., and Drucker, D.J.  Enteroendocrine Localization of GLP-2 Receptor Expression in Humans and Rodents Gastroenterology 2000 119: 744-755

Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas Diabetes. 2000 May;49(5):741-8

Scrocchi, L.A., Hill, M.E., Saleh, J., Perkins, B., and Drucker, D.J. Elimination of GLP-1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action Diabetes 2000 49:1552-1560

Baggio, L., Adatia, F., Bock, T., Brubaker, P.L., Drucker, D.J Sustained expression of exendin-4 does not perturb glucose homeostasis, β cell mass or food intake in metallothionein-preproexendin transgenic mice J. Biol. Chem. 2000 275: 34471-34477

Bernardo Yusta, Robin P. Boushey, and Daniel J. Drucker The Glucagon-like Peptide-2 Receptor Mediates Direct Inhibition of Cellular Apoptosis via a cAMP-dependent Protein Kinase-independent Pathway J. Biol. Chem. 2000 275: 35345-35352.

DaCambra, M.P. Yusta,B., Sumner-Smith,M., Crivici, A., Brubaker, P.L., Drucker, D.J. Structural determinants for activity of Glucagon-like peptide-2. Biochemistry 2000 39: 8888 - 8894

Elias, C.F., Kelly, J.F., Lee, C.E., Ahima, R.S., Drucker, D.J., Saper, C.B., and Elmquist, J.K. Chemical characterization of leptin-activated neurons in the rat brain Journal of Comparative Neurology 2000 43:261-281

Lovshin J, Drucker DJ. New frontiers in the biology of GLP-2. Regul Pept. 2000 Jun 30;90(1-3):27-32

Marguet D, Baggio L, Kobayashi T, Bernard AM, Pierres M, Nielsen PF, Ribel U, Watanabe T, Drucker DJ, Wagtmann N Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 Proc Natl Acad Sci U S A 2000 97(12):6874-6879

Xiao Q, Boushey RP, Cino M, Drucker DJ, Brubaker PL Circulating levels of glucagon-like peptide-2 in human subjects with inflammatory bowel disease. 1: Am J Physiol Regul Integr Comp Physiol 2000 Apr;278(4):R1057-63

MacLusky, N.J., Cook, S., Scrocchi, L.A., Shin, J., Kim, J., Vaccarino, F., Asa, S.L. and Drucker, D.J. Neuroendocrine function in mice with complete disruption of GLP-1 receptor signaling Endocrinology 2000 141:752-62.


Drucker, D.J., DeForest, L., Yusta, B., Boushey, R.P. and Brubaker, P.L. Enhancement of intestinal epithelial repair by h[Gly2]-GLP-2 in a murine model of ulcerative colitis 1999 Am J Physiol 276:G79-G91

Munroe, D.G. Gupta, A.K., Kooshesh,P., Vyas, T.B., Rizkalla, G., Wang,H., Demchyshyn,L., Kamboj, R.K., McCallum, K., Sumner-Smith, M., Drucker, D.J., and Crivici, A. Prototypic G protein coupled receptor for the intestinotrophic factor glucagon-like peptide 2 1999 Proc. Natl. Acad. Sci (USA) 96:1569-1573

Kaestner, K.H., Katz, K., Liu, Y., Drucker, D.J. and Schutz, G. Inactivation of the winged helix transcription factor HNF3a affects glucose homeostasis and islet glucagon gene expression in vivo 1999 Genes & Development 13:495-504

Trinh K.Y., Jin, T., and Drucker, D.J. Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3 1999 J. Biol.Chem. 274:6011-6019

Drucker D. Glucagon-like peptide 2 1999 Trends in Endocrinology and Metabolism 10:153-156

Xiao, Q., Boushey, R.P., Drucker, D.J., and Brubaker, P.L. Secretion of the intestinotropic hormone glucagon-like peptide-2 is differentially regulated by nutrients in humans 1999 Gastroenterology 17:99-105

Hill, F.M., Asa, S.L., and Drucker, D.J. Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription 1999 Mol Endocrinol 13(9):1474-86

Drucker DJ, Boushey RP, Wang F, Hill ME, Brubaker PL, Yusta B Biologic properties and therapeutic potential of glucagon-like peptide-2 1999 J Parenter Enteral Nutr 23:S98-100

Daisy Flamez, Patrick Gilon, Karen Moens, An Van Breusegem, Dominique Delmeire, Louise A. Scrocchi, Jean-Claude Henquin, Daniel J. Drucker, and Frans Schuit Altered cAMP and Ca2+ signaling in mouse pancreatic islets with GLP-1 receptor null phenotype 1999 Diabetes 48:1979-1986

Yusta, B., Somwar, R., Wang, F., Munroe, D., Grinstein, S., Klip, A., and Drucker, D.J. Identification of GLP-2 activated signaling pathways in BHK fibroblasts expressing the rat GLP-2 receptor 1999 J. Biol. Chem. 274:30459-30467.

Boushey, R.P. Yusta, B., and Drucker, D. J. Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis 1999 Am J Physiol 277: E937-E947

Nian, M., Drucker, D.J., Irwin D. Divergent regulation of human and rat proglucagon gene promoters in vivo. 1999 Am J Physiol 277:G829-37


Drucker D.J. The glucagon-like peptides. Diabetes 1998 47:159-169

Flamez, D., Breusegem, A.V., Scrocchi, L.A., Quartier, E., Pipeleers, D., Drucker, D.J., Schuit, F. Mouse pancreatic ß cells exhibit preserved glucose competence after disruption of the GLP-1 Receptor gene 1998 Diabetes 47: 646-652

Scrocchi, L.A., Marshall, B.A., Cook, S.M., Brubaker, P.L., and Drucker, D.J. Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling 1998 Diabetes 47: 632-639

Scrocchi, L.A. and Drucker D.J. Effects of aging and a high fat diet on body weight and glucose tolerance in GLP-1R-/- mice 1998 Endocrinology 139:3127-32

Pederson, R.A., Satkunarajah,M. McIntosh,C.H.S., Scrocchi,L.A., Flamez,D., Schuit,F., Drucker, D.J. and Wheeler, M.B. Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice 1998 Diabetes 47:1046-52.

Brubaker, P.L., Schloos, J., and Drucker, D.J. Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line 1998 Endocrinology 139:4108-4114

Serre,V., Dolci,W., Scrocchi, L.A., Drucker, D. J., Efrat,S., and Thorens, B. Exendin-(9-39) as an inverse agonist of the GLP-1 receptor. Implications for basal intracellular cAMP levels and ß cell glucose competence 1998 Endocrinology 139(11):4448-54


Jin T., Trinh, D.K.Y., Wang, F., and Drucker, D.J. The Caudal homeobox gene cdx-2/3 activates endogenous proglucagon gene expression in InR1-G9 islet cells Mol Endocrinol 1997 11:203-209

Chen E., and Drucker, D.J. Tissue-specific expression of mRNAs with different open reading frames that encode proglucagon -derived peptides and exendin 4 in the lizard J. Biol. Chem. 1997 272:4108-4115

Tsai C.-H., Hill, M., and Drucker, D.J. Biological determinants of intestinotrophic properties of GLP-2 in vivo Am. J. Physiol. 1997 272:G662-G668

Brubaker, P.L. Izzo, A., Hill, M., and Drucker, D.J. Intestinal function in mice with small bowel growth induced by glucagon-like peptide 2. Am. J. Physiol.1997 272: E1050 - E1058

Tsai A., Hill, M., Asa, S.L., Brubaker, P.L., and Drucker, D.J. Intestinal growth-promoting properties of glucagon-like peptide 2 in mice. Am. J. Physiol. 1997 Jul;273(1 Pt 1):E77-84

Brubaker PL, Crivici A, Izzo A, Ehrlich P, Tsai CH, Drucker DJ. Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2. Endocrinology. 1997 Nov;138(11):4837-4843

Drucker D.J., Shi, Q., Crivici, A., Sumner-Smith, M., Tavares, W., Hill, M. DeForest, L., Cooper, S., and Brubaker, P.L. Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV Nature Biotechnology 1997 15:673-677

Drucker D.J. Intestinal growth factors. Am. J. Physiol. 1997 273:G3-G6

Fischer K.D., Dhanvantari, S., Drucker, D.J. and Brubaker, P.L. Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats Am. J. Physiol. 1997 273:E815-E820

Drucker D. J., DeForest, L., and Brubaker, P.L. Intestinal response to growth factors administered alone or in combination with h[Gly2]-GLP-2 Am. J. Physiol. 1997 273:G1252-G1262

Scrocchi L.A., Brown, T.J., and Drucker, D.J. Leptin sensitivity in non-obese GLP-1 receptor-/- mice Diabetes 1997 46: 2029-2034


Scrocchi, L.S., Brown,T.J., MacLusky,N., Brubaker, P.L., Auerbach,A.B., Joyner, A.L. and Drucker, D.J. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene Nat Med 1996 Nov;2(11):1254-8.

Jin T., and Drucker D.J.Activation of proglucagon gene transcription through a novel G1 promoter element by the caudal-related homeobox protein cdx-3 Mol Cell Biol 1996 16: 19-28

Slingerland J.M., Petrocelli, T., Poon, R., Drucker D.J. and Rosen, C.F. UVB Radiation mediates S phase checkpoint via induction of p21 Cip/Waf1 Oncogene 1996 12:1387-1396

Wang M., and Drucker D.J. Activation of amylin gene transcription by the LIM domain homeobox gene isl-1 Mol Endo 1996 10:243-251

Asa S.L., Lee, Y.C., and Drucker, D.J. Development of colonic and pancreatic endocrine tumors in mice expressing a glucagon-SV40 T antigen transgene Virchows Archives 1996 427:595-606

Shi Z.Q., Rastogi, K.S., Lekas, M., Efendic, S., Drucker, D.J., and Vranic, M. Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats Endocrinology 1996 137:3193-3199

Drucker D.J., Ehrlich, P., Asa, S.L., Brubaker, P.L. Induction of epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. 1996 93:7911-7916

Lu F., Jin,T., and Drucker, D.J. Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line. Endocrinology 1996 137:3710-3716.

1995 and miscellaneous

Rosen C.F., Chang, R., and Drucker D.J.. Identification of novel UVB-induced genes in rat keratinocytes. Am. J. Physiol 1995 268:C846-C855

Wang M., and Drucker D.J. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription J. Biol. Chem 1995 270:12646-12652

Jin T., and Drucker D. J. The proglucagon gene upstream enhancer contains positive and negative domains important for tissue-specific proglucagon gene transcription Mol Endo 1995 9:1306-1320

Drucker D. J., Jin, T., Asa, S. L., Young, T. A., and Brubaker, P.L. Activation of proglucagon gene transcription by protein kinase A in a novel mouse enteroendocrine cell line. Mol Endo 1994 8:1646-1655

Campos, R.V., Lee, Y.C., Drucker, D. J. Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology 1994 May;134(5):2156-64.

Drucker D. J., Lee YC, Asa SL, Brubaker PL. Inhibition of pancreatic glucagon gene expression in mice bearing a subcutaneous glucagon-producing GLUTag transplantable tumor Mol Endocrinol. 1992 Dec;6(12):2175-84

Drucker D. J., Lee YC, Asa SL, Brubaker PL Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine Proc. Natl. Acad. Sci (USA) 1989 Jun;86(11):3953-7.

Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., Habener J. F. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line Proc. Natl. Acad. Sci(USA) 1987 May;84(10):3434-8


The publications listed above are provided for information and use for Drucker lab members. Third parties wishing to obtain reprints should, where appropriate, contact the specific Journal.